Autophagy in normal hematopoiesis and leukemia: Biological and therapeutic implications

Hendrik Folkerts

    Research output: ThesisThesis fully internal (DIV)

    657 Downloads (Pure)

    Abstract

    All together the studies in this thesis show that autophagy is an essential survival mechanism for both normal hematopoietic and AML cells and MDS erythroblasts. Altered expression of autophagy-associated genes might have consequences for drug resistance. Therefore, these findings suggest that inhibition of autophagy might be a promising therapeutic strategy for the treatment of AML.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Vellenga, Edo, Supervisor
    • Schuringa, Jan Jacob, Supervisor
    • Coffer, Paul J., Supervisor, External person
    Award date25-Mar-2019
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-6375-301-2
    Publication statusPublished - 2019

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