Autophagy: Principles and significance in health and disease

V. Todde, M Veenhuis, I.J. van der Klei

Research output: Contribution to journalReview articlepeer-review

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Abstract

Degradation processes are important for optimal functioning of eukaryotic cells. The two major protein degradation pathways in eukaryotes are the ubiquitin-proteasome pathway and autophagy. This contribution focuses on autophagy. This process is important for survival of cells during nitrogen starvation conditions but also has a house keeping function in removing exhausted, redundant or unwanted cellular components. We present an overview of the molecular mechanism involved in three major autophagy pathways: chaperone mediated autophagy, microautophagy and macroautophagy. Various recent reports indicate that autophagy plays a crucial role in human health and disease. Examples are presented of lysosomal storage diseases and the role of autophagy in cancer, neurodegenerative diseases, defense against pathogens and cell death. (C) 2008 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalBiochimica et biophysica acta-Molecular basis of disease
Volume1792
Issue number1
DOIs
Publication statusPublished - Jan-2009

Keywords

  • Yeast
  • Autophagy
  • ATG genes
  • Vacuole
  • Lysosome
  • Autophagosome
  • VACUOLE TARGETING PATHWAY
  • YEAST HANSENULA-POLYMORPHA
  • SELECTIVE PEROXISOME DEGRADATION
  • PICHIA-PASTORIS REQUIRES
  • GENOME-WIDE ASSOCIATION
  • SACCHAROMYCES-CEREVISIAE
  • CELL-DEATH
  • PROTEIN-KINASE
  • PIECEMEAL MICROAUTOPHAGY
  • CORONAVIRUS REPLICATION

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