Autophagy regulation through Atg9 traffic

Sharon A Tooze, Fulvio Reggiori

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42 Citations (Scopus)
26 Downloads (Pure)

Abstract

Rapid membrane expansion is the key to autophagosome formation during nutrient starvation. In this issue, Yamamoto et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201202061) now provide a mechanism for vesicle-mediated initiation of autophagosome biogenesis. They show that Atg9 vesicles, produced de novo during starvation, are ∼30-60 nm in size and contain ∼30 molecules of Atg9. These vesicles assemble to form an autophagosome, and subsequently, the Atg9 embedded in the outer membrane is recycled to avoid degradation.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalThe Journal of Cell Biology
Volume198
Issue number2
DOIs
Publication statusPublished - 23-Jul-2012
Externally publishedYes

Keywords

  • Intracellular Membranes
  • Membrane Proteins
  • Phagosomes
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins

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