Autophagy regulation through Atg9 traffic

Sharon A Tooze, Fulvio Reggiori

Research output: Contribution to journalEditorialAcademicpeer-review

42 Citations (Scopus)
26 Downloads (Pure)


Rapid membrane expansion is the key to autophagosome formation during nutrient starvation. In this issue, Yamamoto et al. (2012. J. Cell Biol. now provide a mechanism for vesicle-mediated initiation of autophagosome biogenesis. They show that Atg9 vesicles, produced de novo during starvation, are ∼30-60 nm in size and contain ∼30 molecules of Atg9. These vesicles assemble to form an autophagosome, and subsequently, the Atg9 embedded in the outer membrane is recycled to avoid degradation.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalThe Journal of Cell Biology
Issue number2
Publication statusPublished - 23-Jul-2012
Externally publishedYes


  • Intracellular Membranes
  • Membrane Proteins
  • Phagosomes
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins

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