Autosomal dominant polycystic kidney disease: Studies on epidemiology and methodology development for clinical trials

This thesis is about ADPKD and epidemical studies and methodology for clinical trial design. Conventional treatments for CKD appear not to halt renal function decline in ADPKD. Importantly, with these data we do not imply that strict blood pressure control, angiotensin-converting-enzyme inhibition, statins, and low-salt and low-protein diets should not be prescribed. Although these treatments may not affect renal survival, they are likely to improve mortality in these patients, especially due to reduced cardiovascular morbidity and mortality. In addition, we investigated new methodology to estimate disease activity. Kidney function We use this new methodology in randomized controlled trials to investigate the efficacy of Lanreotide to halt renal function decline in ADPKD patients.