Axillary recurrence rate after negative sentinel node biopsy in breast cancer - Three-year follow-up of the Swedish Multicenter Cohort Study

Leif Bergkvist, Jana de Boniface*, Per-Ebbe Jonsson, Christian Ingvar, Goeran Liljegren, Jan Frisell, Swedish Breast Canc Grp, Swedish Soc Breast Surg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

75 Citations (Scopus)

Abstract

Background: Sentinel lymph node biopsy is an established staging method in early breast cancer. After a negative biopsy, most institutions will not perform a completion axillary dissection. The present study reports the current axillary recurrence (AR) rate, overall and disease-free survival in the Swedish Multicenter Cohort Study.

Methods: From 3534 patients with primary breast cancer

Results: After a median follow-up time of 37 months (0-75), the axilla was the sole initial site of recurrence in 13 patients (13 of 2246, 0.6%). In another 7 patients, axillary relapse occurred after or concurrently with a local recurrence in the breast, and in a further 7 cases, it coincided with distant or extra-axillary lymphatic metastases. Thus, a total of 27 ARs were identified (27 of 2246, 1.2%). The overall 5-year survival was 91.6% and disease-free survival 92.1%.

Conclusions: This is the first report from a national multicenter study that covers, not only highly specialized institutions but also small community hospitals with just a few procedures per year. Despite this heterogeneous background, the results lie well within the range of AR rates published internationally (0%-3.6%). The sentinel node biopsy procedure seems to be safe in a multicenter setting. Nevertheless, long-term follow-up data should be awaited before firm conclusions are drawn.

Original languageEnglish
Pages (from-to)150-156
Number of pages7
JournalAnnals of Surgery
Volume247
Issue number1
DOIs
Publication statusPublished - Jan-2008

Keywords

  • LYMPH-NODE
  • CLINICAL EXAMINATION
  • PREDICTIVE FACTORS
  • DISSECTION
  • ULTRASOUND
  • METASTASES
  • CLEARANCE
  • SURVIVAL
  • RELAPSE
  • IMPACT

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