B Cell Activation and Escape of Tolerance Checkpoints: Recent Insights from Studying Autoreactive B Cells

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Abstract

Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the production of autoantibodies, secretion of cytokines, and presentation of autoantigens to T cells. However, the mechanisms that underlie the development of autoreactive B cells are not well understood. Here, we review recent studies leveraging novel techniques to identify and characterize (auto)antigen-specific B cells. The insights gained from such studies pertaining to the mechanisms involved in the escape of tolerance checkpoints and the activation of autoreactive B cells are discussed. In addition, we briefly highlight potential therapeutic strategies to target and eliminate autoreactive B cells in autoimmune diseases.

Original languageEnglish
Article number1190
Number of pages18
JournalCells
Volume10
Issue number5
DOIs
Publication statusPublished - May-2021

Keywords

  • autoimmune diseases
  • B cells
  • autoreactive B cells
  • tolerance
  • IMMUNOGLOBULIN VARIABLE REGION
  • SYSTEMIC-LUPUS-ERYTHEMATOSUS
  • PRIMARY SJOGRENS-SYNDROME
  • N-GLYCOSYLATION SITES
  • PERIPHERAL-BLOOD
  • T-CELLS
  • RHEUMATOID-ARTHRITIS
  • DEPLETION THERAPY
  • RITUXIMAB
  • AUTOANTIBODIES

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