B cells critical for outcome in high grade serous ovarian carcinoma

Annegé Vledder, Sterre T Paijens, Dominik Loiero, Alexis Maagdenberg, Evelien W Duiker, Joost Bart, Anne M Hendriks, Mathilde Jalving, Naomi Werner, Nienke van Rooij, Annechien Plat, G Bea A Wisman, Refika Yigit, Thijs Roelofsen, Arnold J Kruse, Nastascha M de Lange, Viktor H Koelzer, Marco de Bruyn, Hans W Nijman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Recent work has shown evidence for the prognostic significance of tumor infiltrating B cells (B-TIL) in high grade serous ovarian carcinoma (HGSOC), the predominant histological subtype of ovarian cancer. However, it remains unknown how the favorable prognosis associated with B-TIL relates to the current standard treatments of primary debulking surgery (PDS) followed by chemotherapy or (neo-)adjuvant chemotherapy (NACT) combined with interval debulking surgery. To address this, we analyzed the prognostic impact of B-TIL in relationship to primary treatment and tumor infiltrating T cell status in a highly homogenous cohort of HGSOC patients. This analysis involved a combined approach utilizing histological data and high-dimensional flow cytometry analysis. Our findings indicate that while HGSOC tumors pre-treated with NACT are infiltrated with tumor-reactive CD8 + and CD4 + TIL subsets, only B-TIL and IgA plasma blasts confer prognostic benefit in terms of overall survival. Importantly, the prognostic value of B-TIL and IgA plasma blasts was not restricted to patients treated with NACT, but was also evident in patients treated with PDS. Together, our data point to a critical prognostic role for B-TIL in HGSOC patients independent of T cell status, suggesting that alternative treatment approaches focused on the activation of B cells should be explored for HGSOC.

Original languageEnglish
Number of pages12
JournalInternational Journal of Cancer
DOIs
Publication statusE-pub ahead of print - 22-Aug-2024

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