BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Alexey Dudnik*, A. Filipa Almeida, Ricardo Andrade, Barbara Avila, Pilar Banados, Diane Barbay, Jean-Etienne Bassard, Mounir Benkoulouche, Michael Bott, Adelaide Braga, Dario Breitel, Rex Brennan, Laurent Bulteau, Celine Chanforan, Ines Costa, Rafael S. Costa, Mahdi Doostmohammadi, Nuno Faria, Chengyong Feng, Armando FernandesPatricia Ferreira, Roberto Ferro, Alexandre Foito, Sabine Freitag, Goncalo Garcia, Paula Gaspar, Joana Godinho-Pereira, Bjorn Hamberger, Andras Hartmann, Harald Heider, Carolina Jardim, Alice Julien-Laferriere, Nicolai Kallscheuer, Wolfgang Kerbe, Oscar P. Kuipers, Shanshan Li, Nicola Love, Alberto Marchetti-Spaccamela, Jan Marienhagen, Cathie Martin, Arnaud Mary, Vincent Mazurek, Camillo Meinhart, David Mendez Sevillano, Regina Menezes, Michael Naesby, Morten H. H. Norholm, Finn T. Okkels, Marcel Ottens, Ana Solopova

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

14 Citations (Scopus)
211 Downloads (Pure)

Abstract

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

Original languageEnglish
Pages (from-to)291-326
Number of pages36
JournalPhytochemistry reviews
Volume17
Issue number2
DOIs
Publication statusPublished - Apr-2018

Keywords

  • Berries
  • Bioprospecting
  • Microbial cell factories
  • Polyphenols
  • Sustainable production

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