Back cover: Enhancing Apoptosome Assembly via Mito-Biomimetic Lipid Nanocarrier for Cancer Therapy (Adv. Funct. Mater. 46/2023)

Huijie Han; Jie Chen; Jiachen Li; Alexandra Correia; Raquel Bártolo; Mohammad-Ali Shahbazi; Tambet Teesalu; Shiqi Wang; Wenguo Cui; Hélder A. Santos

doi:10.1002/adfm.202370275

Back cover: Enhancing Apoptosome Assembly via Mito-Biomimetic Lipid Nanocarrier for Cancer Therapy (Adv. Funct. Mater. 46/2023)

Huijie Han, Jie Chen, Jiachen Li, Alexandra Correia, Raquel Bártolo, Mohammad-Ali Shahbazi, Tambet Teesalu, Shiqi Wang, Wenguo Cui, Hélder A. Santos

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Abstract

Mito-Biomimetic Lipid Nanocarriers In article number 2305316, Shiqi Wang, Wenguo Cui, Hélder A. Santos, and co-workers show that when cytochrome C and lonidamine co-loaded liposomes enter breast cancer cells, they release the cytochrome C out, which binds with Apaf-1 protein and then assembles into apoptosomes. Since the binding of Cytochrome C and Apaf-1 is prevented by high intracellular ATP levels, the glycolysis inhibitor lonidamine can then reduce ATP and sensitize cytochrome C-induced apoptosome assembly and lead to apoptosis.

Original language	English
Edition	46
DOIs	https://doi.org/10.1002/adfm.202370275
Publication status	Published - 9-Nov-2023

Keywords

apoptosis
apoptosome
cancer therapy
cytochrome c
nanoparticles

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Enhancing Apoptosome Assembly via Mito-Biomimetic Lipid Nanocarrier for Cancer Therapy
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abstract = "Mito-Biomimetic Lipid Nanocarriers In article number 2305316, Shiqi Wang, Wenguo Cui, H{\'e}lder A. Santos, and co-workers show that when cytochrome C and lonidamine co-loaded liposomes enter breast cancer cells, they release the cytochrome C out, which binds with Apaf-1 protein and then assembles into apoptosomes. Since the binding of Cytochrome C and Apaf-1 is prevented by high intracellular ATP levels, the glycolysis inhibitor lonidamine can then reduce ATP and sensitize cytochrome C-induced apoptosome assembly and lead to apoptosis.",

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AU - Han, Huijie

AU - Chen, Jie

AU - Li, Jiachen

AU - Correia, Alexandra

AU - Bártolo, Raquel

AU - Shahbazi, Mohammad-Ali

AU - Teesalu, Tambet

AU - Wang, Shiqi

AU - Cui, Wenguo

AU - Santos, Hélder A.

PY - 2023/11/9

Y1 - 2023/11/9

N2 - Mito-Biomimetic Lipid Nanocarriers In article number 2305316, Shiqi Wang, Wenguo Cui, Hélder A. Santos, and co-workers show that when cytochrome C and lonidamine co-loaded liposomes enter breast cancer cells, they release the cytochrome C out, which binds with Apaf-1 protein and then assembles into apoptosomes. Since the binding of Cytochrome C and Apaf-1 is prevented by high intracellular ATP levels, the glycolysis inhibitor lonidamine can then reduce ATP and sensitize cytochrome C-induced apoptosome assembly and lead to apoptosis.

AB - Mito-Biomimetic Lipid Nanocarriers In article number 2305316, Shiqi Wang, Wenguo Cui, Hélder A. Santos, and co-workers show that when cytochrome C and lonidamine co-loaded liposomes enter breast cancer cells, they release the cytochrome C out, which binds with Apaf-1 protein and then assembles into apoptosomes. Since the binding of Cytochrome C and Apaf-1 is prevented by high intracellular ATP levels, the glycolysis inhibitor lonidamine can then reduce ATP and sensitize cytochrome C-induced apoptosome assembly and lead to apoptosis.

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KW - cytochrome c

KW - nanoparticles

U2 - 10.1002/adfm.202370275

DO - 10.1002/adfm.202370275

M3 - Digital or Visual Products

VL - 33

ER -

Back cover: Enhancing Apoptosome Assembly via Mito-Biomimetic Lipid Nanocarrier for Cancer Therapy (Adv. Funct. Mater. 46/2023)

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