Backgrounds of antibiotic-loaded bone cement and prosthesis-related infection

JGE Hendriks, [No Value] van Horn, HC van der Mei, HJ Busscher*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

259 Citations (Scopus)

Abstract

Antibiotic-loaded bone cement has been in use for over 30 years for the fixation of total joint arthroplasties, although its mechanism of action is still poorly understood. This review presents the backgrounds of bone cements, prosthesis-related infection and antibiotic-loaded bone cements. It is shown that antibiotic-loaded bone cement has a significant effect on bacteria, particularly in animal and clinical studies. However, recently, antimicrobial resistance among bacteria has been ascribed to the antibiotic-loaded bone cement. The unresolved issues both regarding the action of antibiotic-loaded bone cement and the nature of the antimicrobial resistance necessitate further research into the interaction of antibiotic-loaded bone cement and bacteria. (C) 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)545-556
Number of pages12
JournalBiomaterials
Volume25
Issue number3
DOIs
Publication statusPublished - Feb-2004

Keywords

  • antimicrobial
  • arthroplasty
  • bacteria
  • bone cement
  • polymethylmethacrylate
  • TOTAL HIP-ARTHROPLASTY
  • TOTAL JOINT ARTHROPLASTY
  • TOTAL KNEE ARTHROPLASTY
  • LATE HEMATOGENOUS INFECTION
  • AUREUS BIOFILM FORMATION
  • SMALL COLONY VARIANTS
  • GENTAMICIN RELEASE
  • ORTHOPEDIC IMPLANTS
  • IMPREGNATED CEMENT
  • OPERATING-ROOM

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