Bacterial multi-solute transporters

D J Slotboom*, T W Ettema, M Nijland, C Thangaratnarajah

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)
120 Downloads (Pure)

Abstract

Bacterial membrane proteins of the SbmA/BacA family are multi-solute transporters that mediate the uptake of structurally diverse hydrophilic molecules, including aminoglycoside antibiotics and antimicrobial peptides. Some family members are full-length ATP-binding cassette (ABC) transporters, whereas other members are truncated homologues that lack the nucleotide-binding domains and thus mediate ATP-independent transport. A recent cryo-EM structure of the ABC transporter Rv1819c from Mycobacterium tuberculosis has shed light on the structural basis for multi-solute transport and has provided insight into the mechanism of transport. Here, we discuss how the protein architecture makes SbmA/BacA family transporters prone to inadvertent import of antibiotics and speculate on the question which physiological processes may benefit from multi-solute transport.

Original languageEnglish
Pages (from-to)3898-3907
Number of pages10
JournalFEBS Letters
Volume594
Issue number23
Early online date18-Aug-2020
DOIs
Publication statusPublished - Dec-2020

Keywords

  • ABC transporter
  • antibiotics uptake
  • Mycobacterium tuberculosis
  • non-specific uptake
  • transport mechanism
  • ESCHERICHIA-COLI SBMA
  • GENETIC-ANALYSIS
  • ANTIMICROBIAL PEPTIDES
  • ABC TRANSPORTER
  • BACA PROTEIN
  • IDENTIFICATION
  • BINDING
  • RESISTANCE
  • MUTATIONS
  • SEQUENCE

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  • oLife Fellowship Programme

    Roos, W. (PI), van der Tak, F. (PI), Zijlstra, W. (PI), Dobos, V. (Postdoc), Heinen, L. (Postdoc), Thangaratnarajah, C. (Postdoc), Hoekzema, M. (Postdoc), Blokhuis, A. (Postdoc), Mascotti, L. (Postdoc), Padin Santos, D. (Postdoc), Chopra, A. (Postdoc), Obermaier, S. (Postdoc), Driver, M. (Postdoc), Moreira Goulart, M. (Postdoc), Sasidharan, S. (Postdoc), Samar Mahapatra, S. (Postdoc), Zylstra, A. (Postdoc), Geiger, Y. (Postdoc), Llopis Lorente, A. (Postdoc), Aschmann, D. (Postdoc) & Kulala Vittala, S. (Postdoc)

    01/04/201931/03/2024

    Project: Research

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