Baseline predictors of response to TNF-α blocking therapy in ankylosing spondylitis

Suzanne Arends*, Eveline van der Veer, Cees G. M. Kallenberg, Elisabeth Brouwer, Anneke Spoorenberg

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)
71 Downloads (Pure)

Abstract

PURPOSE OF REVIEW: Identifying the characteristics of patients with ankylosing spondylitis (AS) before start of treatment which are able to predict a beneficial response to tumor necrosis factor-alpha (TNF-α) blocking therapy is relevant, especially in view of the high costs and potential side-effects of these agents. This review provides an overview of clinical trials and observational studies investigating baseline predictors of response after 3-6 months of TNF-α blocking therapy and baseline predictors of long-term anti-TNF-α treatment continuation in AS.

RECENT FINDINGS: In multiple studies, increased acute phase reactants, higher disease activity, higher functional status, younger age, and HLA-B27 positivity were identified as independent baseline predictors of achieving clinical response to TNF-α blocking therapy. Increased acute phase reactants, presence of peripheral arthritis, and male sex were repeatedly identified as independent baseline predictors of anti-TNF-α treatment continuation.

SUMMARY: Several studies using multivariate analyses identified comparable baseline predictors of response and/or continuation of TNF-α blocking therapy. The single predictors identified have, at best, moderate capacity to predict treatment response in the individual patient. The development of a prediction model may lead to a more robust instrument to support physicians in decision making on TNF-α blocking therapy in AS in daily clinical practice.

Original languageEnglish
Pages (from-to)290-298
Number of pages9
JournalCURRENT OPINION IN RHEUMATOLOGY
Volume24
Issue number3
DOIs
Publication statusPublished - May-2012

Keywords

  • ankylosing spondylitis
  • biomarkers
  • predictors
  • TNF-alpha blocking therapy
  • treatment response
  • NECROSIS FACTOR TREATMENT
  • PLACEBO-CONTROLLED TRIAL
  • MAJOR CLINICAL-RESPONSE
  • AXIAL SPONDYLOARTHRITIS
  • DISEASE-ACTIVITY
  • DOUBLE-BLIND
  • 2010 UPDATE
  • ETANERCEPT
  • SAFETY
  • INFLIXIMAB

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