Basic aspects of the regeneration of small-calibre neoarteries in biodegradable vascular grafts in rats

Ch. R. H. Wildevuur*, B. van der Lei, J. M. Schakenraad

*Corresponding author for this work

    Research output: Contribution to journalReview articleAcademicpeer-review

    15 Citations (Scopus)

    Abstract

    In this report, an overview is given of the research concerning the development of a new type of small-calibre vascular graft: a hydrophilic, microporous, compliant, biodegradable graft is presented, which functions as a temporary scaffold for the regeneration of a new arterial wall (neoartery). The basic healing process, the distinct effects of hydrophilicity, microporosity, compliance and biodegradation, the smooth muscle cell orientation and the effect of cell-seeding on this healing process in these grafts are described and discussed.

    It is concluded that vascular grafts, prepared from a material of optimal hydrophilicity, microporosity, compliance and rate of biodegradation, combined with smooth muscle and/or endothelial cell-seeding may provide a rapid development of a neoartery independent of the graft length.
    Original languageEnglish
    Pages (from-to)418-422
    Number of pages5
    JournalBiomaterials
    Volume8
    Issue number6
    DOIs
    Publication statusPublished - Nov-1987

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