Abstract
In this report, an overview is given of the research concerning the development of a new type of small-calibre vascular graft: a hydrophilic, microporous, compliant, biodegradable graft is presented, which functions as a temporary scaffold for the regeneration of a new arterial wall (neoartery). The basic healing process, the distinct effects of hydrophilicity, microporosity, compliance and biodegradation, the smooth muscle cell orientation and the effect of cell-seeding on this healing process in these grafts are described and discussed.
It is concluded that vascular grafts, prepared from a material of optimal hydrophilicity, microporosity, compliance and rate of biodegradation, combined with smooth muscle and/or endothelial cell-seeding may provide a rapid development of a neoartery independent of the graft length.
It is concluded that vascular grafts, prepared from a material of optimal hydrophilicity, microporosity, compliance and rate of biodegradation, combined with smooth muscle and/or endothelial cell-seeding may provide a rapid development of a neoartery independent of the graft length.
| Original language | English |
|---|---|
| Pages (from-to) | 418-422 |
| Number of pages | 5 |
| Journal | Biomaterials |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov-1987 |