Bath and Shower Effects in the Rat Parotid Gland Explain Increased Relative Risk of Parotid Gland Dysfunction After Intensity-Modulated Radiotherapy

Peter van Luijk*, Hette Faber, Jacobus M. Schippers, Sytze Brandenburg, Johannes A. Langendijk, Harm Meertens, Robert P. Coppes

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    49 Citations (Scopus)
    27 Downloads (Pure)

    Abstract

    Purpose: To assess in a rat model whether adding a subtolerance dose in a region adjacent to a high-dose irradiated subvolume of the parotid gland influences its response (bath-and-shower effect).

    Methods and Materials: Irradiation of the whole, cranial 50%, and/or the caudal 50% of the parotid glands of Wistar rats was performed using 150-MeV protons. To determine suitable (i.e., subtolerance) dose levels for a bath-dose, both whole parotid glands were irradiated with 5 to 25 Gy. Subsequently groups of Wistar rats received 30 Gy to the caudal 50% (shower) and 0 to 10 Gy to the cranial 50% (bath) of both parotid glands. Stimulated saliva flow rate (function) was measured before and up to 240 days after irradiation.

    Results : Irradiation of both glands up to a dose of 10 Gy did not result in late loss of function and is thus regarded subtolerance. Addition of a dose bath of I to 10 Gy to a high-dose in the caudal 50% of the glands resulted in enhanced function loss.

    Conclusion: Similar to the spinal cord, the parotid gland demonstrates a bath and shower effect, which may explain the less-than-expected sparing of function after IMRT. (C) 2009 Elsevier Inc.

    Original languageEnglish
    Pages (from-to)1002-1005
    Number of pages4
    JournalInternational Journal of Radiation Oncology Biology Physics
    Volume74
    Issue number4
    DOIs
    Publication statusPublished - 15-Jul-2009

    Keywords

    • Radiotherapy
    • Normal tissue damage
    • Parotid gland
    • Xerostomia
    • Dose-volume effects
    • CERVICAL-SPINAL-CORD
    • SALIVARY-GLANDS
    • PROTON-BEAMS
    • NECK-CANCER
    • VOLUME
    • IRRADIATION
    • RADIOSENSITIVITY
    • TOLERANCE
    • DOSIMETRY
    • HEAD

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