Bayesian versus frequentist analysis of multiple quantitative trait loci with an application to an outbred apple cross

C. Maliepaard, M.J. Sillanpää, J.W. van Ooijen, R.C. Jansen, E. Arjas

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Abstract

Two methods, following different statistical paradigms for mapping multiple quantitative trait loci (QTLs), were compared: the first is a frequentist, the second a Bayesian approach. Both methods were applied to previously published experimental data from an outbred progeny of a single cross between two apple cultivars (Malus pumila Mill.). These approaches were compared with respect to (1) the models used, (2) the number of putative QTLs, (3) their estimated map positions and accuracies thereof and (4) the choice of cofactor markers. In general, the strongest evidence for QTLs, provided by both methods, was for the same linkage groups and for similar map positions. However, some differences were found with respect to evidence for QTLs on other linkage groups. The effect of using cofactor markers which were selected differently was also somewhat different.
Original languageEnglish
Pages (from-to)1243-1253
Number of pages11
JournalTheoretical and Applied Genetics
Volume103
Issue number8
DOIs
Publication statusPublished - 2001

Keywords

  • MQM
  • Classical statistics
  • Bayesian inference
  • Comparison
  • QTL mapping methods

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