Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjogren's syndrome

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Abstract

Histopathological assessment of salivary gland biopsies is an important element of the diagnostic work-up of Sjögren's syndrome (SS) (Fox, 2017; Kroese et al., 2018). Microscopic evaluation of salivary glands of primary SS (pSS) patients reveals characteristic periductal lymphocytic infiltrates (foci), which mainly consist of T- and B-lymphocytes, as well as a variety of non-lymphoid cells, including dendritic cells and macrophages. Over time, these infiltrates may become organised to ectopic lymphoid tissue with T/B cell compartmentalisation, presence of CD21+ follicular dendritic cell (FDC) networks and high endothelial venules (Fisher et al., 2017; Kroese et al., 2014; Kroese et al., 2018; Salomonsson et al., 2003).

Original languageEnglish
Pages (from-to)707-710
Number of pages4
JournalOral diseases
Volume26
Issue number3
Early online date7-Jan-2020
DOIs
Publication statusPublished - 28-Jan-2020

Keywords

  • B-cell hyperactivity
  • germinal centre
  • lymphoid organisation
  • primary Sjogren's syndrome
  • LYMPHOID ORGANIZATION
  • STANDARDIZATION
  • HISTOPATHOLOGY

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