Abstract
Histopathological assessment of salivary gland biopsies is an important element of the diagnostic work-up of Sjögren's syndrome (SS) (Fox, 2017; Kroese et al., 2018). Microscopic evaluation of salivary glands of primary SS (pSS) patients reveals characteristic periductal lymphocytic infiltrates (foci), which mainly consist of T- and B-lymphocytes, as well as a variety of non-lymphoid cells, including dendritic cells and macrophages. Over time, these infiltrates may become organised to ectopic lymphoid tissue with T/B cell compartmentalisation, presence of CD21+ follicular dendritic cell (FDC) networks and high endothelial venules (Fisher et al., 2017; Kroese et al., 2014; Kroese et al., 2018; Salomonsson et al., 2003).
Original language | English |
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Pages (from-to) | 707-710 |
Number of pages | 4 |
Journal | Oral diseases |
Volume | 26 |
Issue number | 3 |
Early online date | 7-Jan-2020 |
DOIs | |
Publication status | Published - 1-Apr-2020 |
Keywords
- B-cell hyperactivity
- germinal centre
- lymphoid organisation
- primary Sjogren's syndrome
- LYMPHOID ORGANIZATION
- STANDARDIZATION
- HISTOPATHOLOGY