Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjogren's syndrome

Uzma Nakshbandi; Erlin A. Haacke; Hendrika Bootsma; Arjan Vissink; Fred K. L. Spijkervet; Bert van der Vegt; Frans G. M. Kroese

doi:10.1111/odi.13276

Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjogren's syndrome

Uzma Nakshbandi^*, Erlin A. Haacke, Hendrika Bootsma, Arjan Vissink, Fred K. L. Spijkervet, Bert van der Vegt, Frans G. M. Kroese

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Histopathological assessment of salivary gland biopsies is an important element of the diagnostic work-up of Sjögren's syndrome (SS) (Fox, 2017; Kroese et al., 2018). Microscopic evaluation of salivary glands of primary SS (pSS) patients reveals characteristic periductal lymphocytic infiltrates (foci), which mainly consist of T- and B-lymphocytes, as well as a variety of non-lymphoid cells, including dendritic cells and macrophages. Over time, these infiltrates may become organised to ectopic lymphoid tissue with T/B cell compartmentalisation, presence of CD21+ follicular dendritic cell (FDC) networks and high endothelial venules (Fisher et al., 2017; Kroese et al., 2014; Kroese et al., 2018; Salomonsson et al., 2003).

Original language	English
Pages (from-to)	707-710
Number of pages	4
Journal	Oral diseases
Volume	26
Issue number	3
Early online date	7-Jan-2020
DOIs	https://doi.org/10.1111/odi.13276
Publication status	Published - 28-Jan-2020

Keywords

B-cell hyperactivity
germinal centre
lymphoid organisation
primary Sjogren's syndrome
LYMPHOID ORGANIZATION
STANDARDIZATION
HISTOPATHOLOGY

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Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjögren's syndromeFinal publisher's version, 598 KBLicence: CC BY

Cite this

@article{b3e49c8a667f4fbfb4d60f828eae9f28,

title = "Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjogren's syndrome",

abstract = "Histopathological assessment of salivary gland biopsies is an important element of the diagnostic work-up of Sj{\"o}gren's syndrome (SS) (Fox, 2017; Kroese et al., 2018). Microscopic evaluation of salivary glands of primary SS (pSS) patients reveals characteristic periductal lymphocytic infiltrates (foci), which mainly consist of T- and B-lymphocytes, as well as a variety of non-lymphoid cells, including dendritic cells and macrophages. Over time, these infiltrates may become organised to ectopic lymphoid tissue with T/B cell compartmentalisation, presence of CD21+ follicular dendritic cell (FDC) networks and high endothelial venules (Fisher et al., 2017; Kroese et al., 2014; Kroese et al., 2018; Salomonsson et al., 2003).",

keywords = "B-cell hyperactivity, germinal centre, lymphoid organisation, primary Sjogren's syndrome, LYMPHOID ORGANIZATION, STANDARDIZATION, HISTOPATHOLOGY",

author = "Uzma Nakshbandi and Haacke, {Erlin A.} and Hendrika Bootsma and Arjan Vissink and Spijkervet, {Fred K. L.} and {van der Vegt}, Bert and Kroese, {Frans G. M.}",

year = "2020",

month = jan,

day = "28",

doi = "10.1111/odi.13276",

language = "English",

volume = "26",

pages = "707--710",

journal = "Oral diseases",

issn = "1354-523X",

publisher = "Wiley",

number = "3",

}

Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjogren's syndrome. / Nakshbandi, Uzma; Haacke, Erlin A.; Bootsma, Hendrika ; Vissink, Arjan ; Spijkervet, Fred K. L.; van der Vegt, Bert ; Kroese, Frans G. M.

In: Oral diseases, Vol. 26, No. 3, 28.01.2020, p. 707-710.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjogren's syndrome

AU - Nakshbandi, Uzma

AU - Haacke, Erlin A.

AU - Bootsma, Hendrika

AU - Vissink, Arjan

AU - Spijkervet, Fred K. L.

AU - van der Vegt, Bert

AU - Kroese, Frans G. M.

PY - 2020/1/28

Y1 - 2020/1/28

N2 - Histopathological assessment of salivary gland biopsies is an important element of the diagnostic work-up of Sjögren's syndrome (SS) (Fox, 2017; Kroese et al., 2018). Microscopic evaluation of salivary glands of primary SS (pSS) patients reveals characteristic periductal lymphocytic infiltrates (foci), which mainly consist of T- and B-lymphocytes, as well as a variety of non-lymphoid cells, including dendritic cells and macrophages. Over time, these infiltrates may become organised to ectopic lymphoid tissue with T/B cell compartmentalisation, presence of CD21+ follicular dendritic cell (FDC) networks and high endothelial venules (Fisher et al., 2017; Kroese et al., 2014; Kroese et al., 2018; Salomonsson et al., 2003).

AB - Histopathological assessment of salivary gland biopsies is an important element of the diagnostic work-up of Sjögren's syndrome (SS) (Fox, 2017; Kroese et al., 2018). Microscopic evaluation of salivary glands of primary SS (pSS) patients reveals characteristic periductal lymphocytic infiltrates (foci), which mainly consist of T- and B-lymphocytes, as well as a variety of non-lymphoid cells, including dendritic cells and macrophages. Over time, these infiltrates may become organised to ectopic lymphoid tissue with T/B cell compartmentalisation, presence of CD21+ follicular dendritic cell (FDC) networks and high endothelial venules (Fisher et al., 2017; Kroese et al., 2014; Kroese et al., 2018; Salomonsson et al., 2003).

KW - B-cell hyperactivity

KW - germinal centre

KW - lymphoid organisation

KW - primary Sjogren's syndrome

KW - LYMPHOID ORGANIZATION

KW - STANDARDIZATION

KW - HISTOPATHOLOGY

U2 - 10.1111/odi.13276

DO - 10.1111/odi.13276

M3 - Article

C2 - 31912593

VL - 26

SP - 707

EP - 710

JO - Oral diseases

JF - Oral diseases

SN - 1354-523X

IS - 3

ER -