Beat shock proteins and atrial fibrillation

Harm H. Kampinga*, Robert H. Henning, Isabelle C. van Gelder, Bianca J. J. M. Brundel

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

In this mini-review, the role of heat shock proteins in susceptability to induction of atrial fibrillation (AF) or in the process of AF is discussed. AF is the most common arrhythmia in humans, is self-perpetuating in nature and hence tends to become more persistent in time. Some studies show a correlation between high Hsp70 (HspA1A) expression in cardiac tissue and a reduced susceptability to induction of postoperative AF. Expression of Hsp70, Hsc70 (HspA8), Hsp40 (DnaJB1), Hsp60 (HspD1), Hsp90 (HspC1) was not associated with progression of AF. However, both correlative studies in human and experimental studies suggest that Hsp27 (HspB1) may delay progression of AF to the more permanent forms and hence Hsp27 might be referred to as a "Beat shock protein".

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalCell stress & chaperones
Volume12
Issue number2
Publication statusPublished - 2007

Keywords

  • STRUCTURAL-CHANGES
  • TRANSGENIC MICE
  • MYOCARDIUM
  • HEAT-SHOCK-PROTEIN-70
  • PHOSPHORYLATION
  • EXPRESSION
  • STABILITY
  • PROTECTS
  • GOAT

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