Benefits and harm of systemic steroids for short- And long-term use in rhinitis and rhinosinusitis: An EAACI position paper

Valerie Hox*, Evelijn Lourijsen, Arnout Jordens, Kristian Aasbjerg, Ioana Agache, Isam Alobid, Claus Bachert, Koen Boussery, Paloma Campo, Wytske Fokkens, Peter Hellings, Claire Hopkins, Ludger Klimek, Mika Mäkelä, Ralph Mösges, Joaquim Mullol, Laura Pujols, Carmen Rondon, Michael Rudenko, Sanna Toppila-SalmiGlenis Scadding, Sophie Scheire, Peter-Valentin Tomazic, Thibaut Van Zele, Martin Wagemann, Job F. M. Van Boven, Philippe Gevaert

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that - potentially severe - side-effects can occur with the accumulation of systemic steroid courses over the years. A consensus document summarizing the benefits of systemic steroids for each upper airway disease type, as well as highlighting the potential harms of this treatment is currently lacking. Therefore, a panel of international experts in the field of Rhinology reviewed the available literature with the aim of providing recommendations for the use of systemic steroids in treating upper airway disease.
Original languageEnglish
Article number1
Number of pages27
JournalClinical and translational allergy
Volume10
Issue number1
DOIs
Publication statusPublished - 3-Jan-2020

Keywords

  • Glucocorticosteroids
  • Rhinitis
  • Rhinosinusitis
  • glucocorticoid
  • acute rhinosinusitis
  • adverse event
  • allergic rhinitis
  • alternative medicine
  • antiinflammatory activity
  • asthma
  • autoimmune disease
  • avascular necrosis
  • calcium balance
  • carbohydrate metabolism
  • cardiovascular disease
  • chronic rhinosinusitis
  • Cushingoid syndrome
  • desensitization
  • diabetes mellitus
  • drug activity
  • drug cost
  • drug effect
  • drug efficacy
  • drug induced disease
  • drug mechanism
  • drug use
  • endocrine disease
  • evidence based medicine
  • eye disease
  • fungal sinusitis
  • gastrointestinal symptom
  • human
  • hyperglycemia
  • hypophysis disease
  • hypothalamus disease
  • hypothalamus hypophysis adrenal system
  • immunosuppressive treatment
  • infection
  • injection site discomfort
  • lipid metabolism
  • long term care
  • medical literature
  • mental disease
  • nose disease
  • nose polyp
  • occupational disease
  • osteoporosis
  • otorhinolaryngology
  • pediatric patient
  • peptic ulcer
  • priority journal
  • protein metabolism
  • review
  • rhinitis
  • risk benefit analysis
  • short course therapy
  • systemic therapy
  • upper respiratory tract infection

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