Bile Composition as a Diagnostic and Prognostic Tool in Liver Transplantation

Research output: Contribution to journalReview articleAcademicpeer-review

7 Citations (Scopus)

Abstract

Bile secretion and composition reflects the functional status of hepatocytes and cholangiocytes. Bile composition can have a role in the assessment of donor grafts before implantation in the recipient. In addition, changes in bile composition after liver transplantation can serve as a diagnostic and prognostic tool to predict posttransplant complications, such as primary nonfunction, acute cellular rejection, or nonanastomotic biliary strictures. With the popularization of liver machine perfusion preservation in the clinical setting, there is a revisited interest in biliary biomarkers to assess graft viability before implantation. This review discusses current literature on biliary biomarkers that could predict or assess liver graft and bile duct viability. Bile composition offers an exciting and novel perspective in the search for reliable hepatocyte and cholangiocyte viability biomarkers.

Original languageEnglish
Pages (from-to)1177-1187
Number of pages11
JournalLiver Transplantation
Volume26
Issue number9
Early online date4-Apr-2020
DOIs
Publication statusPublished - 11-Jul-2020

Keywords

  • NORMOTHERMIC MACHINE PERFUSION
  • ACUTE CELLULAR REJECTION
  • DUCT INJURY
  • BILIARY STRICTURES
  • LIPID-COMPOSITION
  • SALT TOXICITY
  • DONOR LIVERS
  • PRESERVATION
  • SECRETION
  • COMPLICATIONS

Cite this