TY - JOUR
T1 - Biochemical markers predictive for bone marrow involvement in systemic mastocytosis
AU - Donker, Marjolein L.
AU - van Doormaal, Jasper J.
AU - van Doormaal, Frederiek F.
AU - Kluin, Philip M.
AU - van der Veer, Eveline
AU - de Monchy, Jan G. R.
AU - Kema, Ido P.
AU - Kluin-Nelemans, Hanneke C.
N1 - Article
PY - 2008/1
Y1 - 2008/1
N2 - Systemic mastocytosis is characterized by bone marrow involvement, which requires a bone marrow biopsy for diagnostic work-up. We questioned whether bone marrow involvement could be predicted using biochemical markers. We selected patients with various symptoms suggestive of indolent systemic mastocytosis, of whom 63 ultimately had bone marrow involvement. Patients suspected of aggressive mastocytosis, or mastocytosis associated with other hematologic diseases were excluded. Evaluation of 115 patients and 15 patient controls demonstrated a test accuracy for serum tryptase, urinary N- methylhistamine and N- methylimidazole acetic acid of 96%, 88% and 95% respectively. These markers provide an excellent pre-test probability of indolent systemic mastocytosis.
AB - Systemic mastocytosis is characterized by bone marrow involvement, which requires a bone marrow biopsy for diagnostic work-up. We questioned whether bone marrow involvement could be predicted using biochemical markers. We selected patients with various symptoms suggestive of indolent systemic mastocytosis, of whom 63 ultimately had bone marrow involvement. Patients suspected of aggressive mastocytosis, or mastocytosis associated with other hematologic diseases were excluded. Evaluation of 115 patients and 15 patient controls demonstrated a test accuracy for serum tryptase, urinary N- methylhistamine and N- methylimidazole acetic acid of 96%, 88% and 95% respectively. These markers provide an excellent pre-test probability of indolent systemic mastocytosis.
KW - mastocytosis
KW - bone marrow involvement
KW - biochemical markers
KW - tryptase
KW - N-iota methylhistamine
KW - N-iota methylimidazole acetic acid
KW - BLOOD MONONUCLEAR-CELLS
KW - C-KIT
KW - MUTATION
KW - ADULTS
KW - URINE
U2 - 10.3324/haematol.11558
DO - 10.3324/haematol.11558
M3 - Article
SN - 0390-6078
VL - 93
SP - 120
EP - 123
JO - Haematologica-the Hematology Journal
JF - Haematologica-the Hematology Journal
IS - 1
ER -