Bioconjugation of metal-based compounds for targeted biomedical applications: from drug delivery to mass spectrometry imaging

Jiaying Han

Research output: ThesisThesis fully internal (DIV)

479 Downloads (Pure)

Abstract

This thesis described the synthesis, carachterization, and application of bioconjugated metal-based compounds. The bioconjugated Pd-based metallocages are non-toxic to healthy tissue cells. Their well defined structure make them ideal tools for targeted delivery of anticancer drug cisplatin. The bioconjugated Ru-based compounds exhibit high photocleavable property which can be used as mass-tag for the targted mass spectrometry imaging of tumor tissue.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • Horvatovich, Peter, Supervisor
  • Bischoff, Rainer, Supervisor
  • Casini, Angela, Supervisor
  • Permentier, Hjalmar, Co-supervisor
Award date7-Feb-2020
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-034-2437-8
Electronic ISBNs978-94-034-2436-1
DOIs
Publication statusPublished - 2020

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