Abstract
Objective: To study the influence of perfluoroalkylsiloxane (PA) surface modification of silicone rubber voice prostheses on biofouling.
Design: Placebo-controlled clinical trial.
Setting: Tertiary referral center, with specialization in head and neck cancer treatment.
Patients: Eighteen consecutive patients with laryngectomies and experienced in the use of a voice prosthesis who visited the outpatient clinic for prosthesis replacement.
Material: Eighteen partially surface-modified voice prostheses (3 with short-chain PAs [1 fluorocarbon unit] and 15 with long-chain PAs [8 fluorocarbon units]) were inserted via the patients' tracheoesophageal shunts and remained in place for 2 to 8 weeks.
Intervention: Replacement of the prostheses.
Main Outcome Measures: Evaluation of biofilm formation on short- and long-chain PA-modified and original silicone rubber surfaces on the esophageal side of the voice prosthesis.
Results: The planimetrical biofilm scores of the surfaces of all 3 short-chain PA-treated voice prostheses indicated more biofouling on the treated surfaces than on the untreated surfaces of the same prostheses. For the long-chain PA-treated prostheses, the planimetrical biofilm scores, as well as the numbers of colony-forming units per cm(-2) for bacteria and yeasts, indicated less biofouling on the created side than on the control side for 9 of the 13 prostheses that could be analyzed (2 were lost to analysis). Identical fungal strains, mainly Candida sp, were isolated from biofilms on each side of the esophageal flange.
Conclusions: Chemisorption of long-chain PAs by the silicone rubber used for voice prostheses reduces biofilm formation in vivo and therefore can be expected to prolong the life of these prostheses. Chemisorption of short-chain PAs by silicone rubber seems to have an adverse effect.
Original language | English |
---|---|
Pages (from-to) | 1329-1332 |
Number of pages | 4 |
Journal | ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY |
Volume | 125 |
Issue number | 12 |
Publication status | Published - Dec-1999 |
Keywords
- RESISTANCE GRONINGEN BUTTON
- TREATED SILICONE-RUBBER
- IN-VITRO
- ADHESION
- YEASTS