Biological and behavioral markers of pain following nerve injury in humans

S A Holmes; N Barakat; M Bhasin; N I Lopez; A Lebel; D Zurakowski; B Thomas; S Bhasin; K E Silva; R Borra; R Burstein; L E Simons; D Borsook

doi:10.1016/j.ynpai.2019.100038

Biological and behavioral markers of pain following nerve injury in humans

S A Holmes^*, N Barakat, M Bhasin, N I Lopez, A Lebel, D Zurakowski, B Thomas, S Bhasin, K E Silva, R Borra, R Burstein, L E Simons, D Borsook

^*Corresponding author for this work

Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

252 Downloads (Pure)

Abstract

The evolution of peripheral and central changes following a peripheral nerve injury imply the onset of afferent signals that affect the brain. Changes to inflammatory processes may contribute to peripheral and central alterations such as altered psychological state and are not well characterized in humans. We focused on four elements that change peripheral and central nervous systems following ankle injury in 24 adolescent patients and 12 age-sex matched controls. Findings include (a) Changes in tibial, fibular, and sciatic nerve divisions consistent with neurodegeneration; (b) Changes within the primary motor and somatosensory areas as well as higher order brain regions implicated in pain processing; (c) Increased expression of fear of pain and pain reporting; and (d) Significant changes in cytokine profiles relating to neuroinflammatory signaling pathways. Findings address how changes resulting from peripheral nerve injury may develop into chronic neuropathic pain through changes in the peripheral and central nervous system.

Original language	English
Article number	100038
Number of pages	12
Journal	Neurobiology of pain
Volume	7
DOIs	https://doi.org/10.1016/j.ynpai.2019.100038
Publication status	Published - 1-Jan-2020

Access to Document

10.1016/j.ynpai.2019.100038Licence: CC BY

Biological and behavioral markers of pain following nerve injury in humansFinal publisher's version, 2.31 MBLicence: CC BY

Handle.net

Persistent link

Cite this

@article{ba61c01e1de546d6a93e1c6408baa10b,

title = "Biological and behavioral markers of pain following nerve injury in humans",

abstract = "The evolution of peripheral and central changes following a peripheral nerve injury imply the onset of afferent signals that affect the brain. Changes to inflammatory processes may contribute to peripheral and central alterations such as altered psychological state and are not well characterized in humans. We focused on four elements that change peripheral and central nervous systems following ankle injury in 24 adolescent patients and 12 age-sex matched controls. Findings include (a) Changes in tibial, fibular, and sciatic nerve divisions consistent with neurodegeneration; (b) Changes within the primary motor and somatosensory areas as well as higher order brain regions implicated in pain processing; (c) Increased expression of fear of pain and pain reporting; and (d) Significant changes in cytokine profiles relating to neuroinflammatory signaling pathways. Findings address how changes resulting from peripheral nerve injury may develop into chronic neuropathic pain through changes in the peripheral and central nervous system.",

author = "Holmes, {S A} and N Barakat and M Bhasin and Lopez, {N I} and A Lebel and D Zurakowski and B Thomas and S Bhasin and Silva, {K E} and R Borra and R Burstein and Simons, {L E} and D Borsook",

note = "{\textcopyright} 2019 Published by Elsevier Inc.",

year = "2020",

month = jan,

day = "1",

doi = "10.1016/j.ynpai.2019.100038",

language = "English",

volume = "7",

journal = "Neurobiology of pain",

issn = "2452-073X",

publisher = "Elsevier",

}

TY - JOUR

T1 - Biological and behavioral markers of pain following nerve injury in humans

AU - Holmes, S A

AU - Barakat, N

AU - Bhasin, M

AU - Lopez, N I

AU - Lebel, A

AU - Zurakowski, D

AU - Thomas, B

AU - Bhasin, S

AU - Silva, K E

AU - Borra, R

AU - Burstein, R

AU - Simons, L E

AU - Borsook, D

PY - 2020/1/1

Y1 - 2020/1/1

N2 - The evolution of peripheral and central changes following a peripheral nerve injury imply the onset of afferent signals that affect the brain. Changes to inflammatory processes may contribute to peripheral and central alterations such as altered psychological state and are not well characterized in humans. We focused on four elements that change peripheral and central nervous systems following ankle injury in 24 adolescent patients and 12 age-sex matched controls. Findings include (a) Changes in tibial, fibular, and sciatic nerve divisions consistent with neurodegeneration; (b) Changes within the primary motor and somatosensory areas as well as higher order brain regions implicated in pain processing; (c) Increased expression of fear of pain and pain reporting; and (d) Significant changes in cytokine profiles relating to neuroinflammatory signaling pathways. Findings address how changes resulting from peripheral nerve injury may develop into chronic neuropathic pain through changes in the peripheral and central nervous system.

AB - The evolution of peripheral and central changes following a peripheral nerve injury imply the onset of afferent signals that affect the brain. Changes to inflammatory processes may contribute to peripheral and central alterations such as altered psychological state and are not well characterized in humans. We focused on four elements that change peripheral and central nervous systems following ankle injury in 24 adolescent patients and 12 age-sex matched controls. Findings include (a) Changes in tibial, fibular, and sciatic nerve divisions consistent with neurodegeneration; (b) Changes within the primary motor and somatosensory areas as well as higher order brain regions implicated in pain processing; (c) Increased expression of fear of pain and pain reporting; and (d) Significant changes in cytokine profiles relating to neuroinflammatory signaling pathways. Findings address how changes resulting from peripheral nerve injury may develop into chronic neuropathic pain through changes in the peripheral and central nervous system.

U2 - 10.1016/j.ynpai.2019.100038

DO - 10.1016/j.ynpai.2019.100038

M3 - Article

C2 - 31890990

SN - 2452-073X

VL - 7

JO - Neurobiology of pain

JF - Neurobiology of pain

M1 - 100038

ER -

Biological and behavioral markers of pain following nerve injury in humans

Abstract

Access to Document

Handle.net

Fingerprint

Cite this