Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease

Heleen Lameijer, Ymkje J. van Slooten, Monique R. M. Jongbloed, Martijn A. Oudijk, Marlies A. M. Kampman, Arie P. van Dijk, Marco C. Post, Barbara J. Mulder, Krystyna M. Sollie, Dirk J. van Veldhuisen, Tjark Ebels, Joost P. van Melle, Petronella G. Pieper*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease.

Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV.

Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) >= 20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19,

Conclusion: Complications occur more often in pregnancies of women with a mechanical PHV than in women with a biological PHV, mainly caused by PHV thrombosis and bleeding complications. Meticulous monitoring of anticoagulation in pregnant women is necessary. Women with a pulmonary mechanical PHV are at high risk of complications. (C) 2018 Published by Elsevier B.V.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalInternational Journal of Cardiology
Volume268
DOIs
Publication statusPublished - 1-Oct-2018

Keywords

  • Prosthetic heart valve
  • Congenital heart disease
  • Pregnancy
  • Anticoagulation
  • EUROPEAN-SOCIETY
  • ANTICOAGULATION
  • COMPLICATIONS
  • REGISTRY
  • BIOPROSTHESIS
  • METAANALYSIS
  • CARDIOLOGY
  • RATIONALE
  • OUTCOMES
  • FAILURE

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