Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease

Heleen Lameijer; Ymkje J. van Slooten; Monique R. M. Jongbloed; Martijn A. Oudijk; Marlies A. M. Kampman; Arie P. van Dijk; Marco C. Post; Barbara J. Mulder; Krystyna M. Sollie; Dirk J. van Veldhuisen; Tjark Ebels; Joost P. van Melle; Petronella G. Pieper

doi:10.1016/j.ijcard.2018.05.038

Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease

Heleen Lameijer, Ymkje J. van Slooten, Monique R. M. Jongbloed, Martijn A. Oudijk, Marlies A. M. Kampman, Arie P. van Dijk, Marco C. Post, Barbara J. Mulder, Krystyna M. Sollie, Dirk J. van Veldhuisen, Tjark Ebels, Joost P. van Melle, Petronella G. Pieper^*

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease.

Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV.

Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) >= 20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19,

Conclusion: Complications occur more often in pregnancies of women with a mechanical PHV than in women with a biological PHV, mainly caused by PHV thrombosis and bleeding complications. Meticulous monitoring of anticoagulation in pregnant women is necessary. Women with a pulmonary mechanical PHV are at high risk of complications. (C) 2018 Published by Elsevier B.V.

Original language	English
Pages (from-to)	106-112
Number of pages	7
Journal	International Journal of Cardiology
Volume	268
DOIs	https://doi.org/10.1016/j.ijcard.2018.05.038
Publication status	Published - 1-Oct-2018

Keywords

Prosthetic heart valve
Congenital heart disease
Pregnancy
Anticoagulation
EUROPEAN-SOCIETY
ANTICOAGULATION
COMPLICATIONS
REGISTRY
BIOPROSTHESIS
METAANALYSIS
CARDIOLOGY
RATIONALE
OUTCOMES
FAILURE

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10.1016/j.ijcard.2018.05.038

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Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease
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Lameijer, H., van Slooten, Y. J., Jongbloed, M. R. M., Oudijk, M. A., Kampman, M. A. M., van Dijk, A. P., Post, M. C., Mulder, B. J., Sollie, K. M., van Veldhuisen, D. J., Ebels, T., van Melle, J. P., & Pieper, P. G. (2018). Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease. International Journal of Cardiology, 268, 106-112. https://doi.org/10.1016/j.ijcard.2018.05.038

Lameijer, Heleen ; van Slooten, Ymkje J. ; Jongbloed, Monique R. M. ; Oudijk, Martijn A. ; Kampman, Marlies A. M. ; van Dijk, Arie P. ; Post, Marco C. ; Mulder, Barbara J. ; Sollie, Krystyna M. ; van Veldhuisen, Dirk J. ; Ebels, Tjark ; van Melle, Joost P. ; Pieper, Petronella G. / Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease. In: International Journal of Cardiology. 2018 ; Vol. 268. pp. 106-112.

@article{fc3cf6edd36b4caea94e7efa8b1df079,

title = "Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease",

abstract = "Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease.Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV.Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) >= 20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19,Conclusion: Complications occur more often in pregnancies of women with a mechanical PHV than in women with a biological PHV, mainly caused by PHV thrombosis and bleeding complications. Meticulous monitoring of anticoagulation in pregnant women is necessary. Women with a pulmonary mechanical PHV are at high risk of complications. (C) 2018 Published by Elsevier B.V.",

keywords = "Prosthetic heart valve, Congenital heart disease, Pregnancy, Anticoagulation, EUROPEAN-SOCIETY, ANTICOAGULATION, COMPLICATIONS, REGISTRY, BIOPROSTHESIS, METAANALYSIS, CARDIOLOGY, RATIONALE, OUTCOMES, FAILURE",

author = "Heleen Lameijer and {van Slooten}, {Ymkje J.} and Jongbloed, {Monique R. M.} and Oudijk, {Martijn A.} and Kampman, {Marlies A. M.} and {van Dijk}, {Arie P.} and Post, {Marco C.} and Mulder, {Barbara J.} and Sollie, {Krystyna M.} and {van Veldhuisen}, {Dirk J.} and Tjark Ebels and {van Melle}, {Joost P.} and Pieper, {Petronella G.}",

year = "2018",

month = oct,

day = "1",

doi = "10.1016/j.ijcard.2018.05.038",

language = "English",

volume = "268",

pages = "106--112",

journal = "International Journal of Cardiology",

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Lameijer, H, van Slooten, YJ, Jongbloed, MRM, Oudijk, MA, Kampman, MAM, van Dijk, AP, Post, MC, Mulder, BJ, Sollie, KM, van Veldhuisen, DJ , Ebels, T , van Melle, JP & Pieper, PG 2018, 'Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease', International Journal of Cardiology, vol. 268, pp. 106-112. https://doi.org/10.1016/j.ijcard.2018.05.038

Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease. / Lameijer, Heleen; van Slooten, Ymkje J.; Jongbloed, Monique R. M.; Oudijk, Martijn A.; Kampman, Marlies A. M.; van Dijk, Arie P.; Post, Marco C.; Mulder, Barbara J.; Sollie, Krystyna M.; van Veldhuisen, Dirk J.; Ebels, Tjark ; van Melle, Joost P.; Pieper, Petronella G.

In: International Journal of Cardiology, Vol. 268, 01.10.2018, p. 106-112.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease

AU - Lameijer, Heleen

AU - van Slooten, Ymkje J.

AU - Jongbloed, Monique R. M.

AU - Oudijk, Martijn A.

AU - Kampman, Marlies A. M.

AU - van Dijk, Arie P.

AU - Post, Marco C.

AU - Mulder, Barbara J.

AU - Sollie, Krystyna M.

AU - van Veldhuisen, Dirk J.

AU - Ebels, Tjark

AU - van Melle, Joost P.

AU - Pieper, Petronella G.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease.Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV.Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) >= 20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19,Conclusion: Complications occur more often in pregnancies of women with a mechanical PHV than in women with a biological PHV, mainly caused by PHV thrombosis and bleeding complications. Meticulous monitoring of anticoagulation in pregnant women is necessary. Women with a pulmonary mechanical PHV are at high risk of complications. (C) 2018 Published by Elsevier B.V.

AB - Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease.Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV.Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) >= 20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19,Conclusion: Complications occur more often in pregnancies of women with a mechanical PHV than in women with a biological PHV, mainly caused by PHV thrombosis and bleeding complications. Meticulous monitoring of anticoagulation in pregnant women is necessary. Women with a pulmonary mechanical PHV are at high risk of complications. (C) 2018 Published by Elsevier B.V.

KW - Prosthetic heart valve

KW - Congenital heart disease

KW - Pregnancy

KW - Anticoagulation

KW - EUROPEAN-SOCIETY

KW - ANTICOAGULATION

KW - COMPLICATIONS

KW - REGISTRY

KW - BIOPROSTHESIS

KW - METAANALYSIS

KW - CARDIOLOGY

KW - RATIONALE

KW - OUTCOMES

KW - FAILURE

U2 - 10.1016/j.ijcard.2018.05.038

DO - 10.1016/j.ijcard.2018.05.038

M3 - Article

VL - 268

SP - 106

EP - 112

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -