Biolubrication enhancement for tissues and biomaterials: Restoration of natural lubricant function by biopolymers

Hongping Wan

    Research output: ThesisThesis fully internal (DIV)

    140 Downloads (Pure)

    Abstract

    Insufficient biolubrication leads to a drastic decrease in the quality of life associated with chronic pain, irritation, and restricted mobility. With the increasing aging population, more and more people worldwide suffer from lubrication dysfunction-related conditions like dry mouth, dry eye, and osteoarthritis, yielding severe discomfort. Currently, the strategy used to restore biolubrication is to overwhelm the natural lubrication system with exogenous viscosity enhancer, which shows limited effect. To improve the quality of life of patients, it is urgent to develop a new strategy to enhance biolubrication. This thesis presents a new approach of utilizing the existing impaired lubricants to repair the lubrication systems with the help of biopolymers. This thesis provides new insights in restoring the lubrication functionality in the living system.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Zuhorn, Inge, Supervisor
    • Herrmann, Andreas, Supervisor
    • Sharma, Prashant, Co-supervisor
    • Kamperman, M.M.G., Assessment committee, External person
    • van der Heide, E., Assessment committee, External person
    • Zhou, F, Assessment committee, External person
    Award date20-Oct-2020
    Place of Publication[Groningen]
    Publisher
    DOIs
    Publication statusPublished - 2020

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