Biomarkers and non-invasive tests for gastrointestinal mucositis

N. S. S. Kuiken, E. H. H. M. Rings, N. M. A. Blijlevens, Wim J. E. Tissing*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)
255 Downloads (Pure)

Abstract

Gastrointestinal mucositis is a complex inflammatory reaction of the mucous membranes, a side effect of both chemotherapy and radiotherapy. Currently, assessment scales are used to diagnose mucositis. However, a biomarker which would determine whether there is mucositis and thereby establish the severity objectively would be very useful. This will give the opportunity to evaluate studies, to determine risk factors and incidence, and it will make it possible to compare studies. Moreover, this biomarker might improve clinical management for patients. In this paper, we reviewed studies concerning potential biomarkers in blood samples and fecal samples, and potential tests in breath samples and urine samples. We include biomarkers and tests studied in animal models and/or in clinical trials, and discuss the validity, diagnostic accuracy, and applicability.

Original languageEnglish
Pages (from-to)2933-2941
Number of pages9
JournalSupportive Care in Cancer
Volume25
Issue number9
DOIs
Publication statusPublished - Sep-2017

Keywords

  • Gastrointestinal mucositis
  • Biomarkers
  • Citrulline
  • SMALL-INTESTINAL MUCOSITIS
  • C-13-SUCROSE BREATH TEST
  • PLASMA CITRULLINE CONCENTRATION
  • METHOTREXATE-INDUCED MUCOSITIS
  • ALIMENTARY-TRACT MUCOSITIS
  • PRO-INFLAMMATORY CYTOKINES
  • HIGH-DOSE CHEMOTHERAPY
  • ACID-BINDING PROTEIN
  • SMALL-BOWEL
  • ENTEROCYTE MASS

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