Biomarkers and personalized medicine in heart failure

    Research output: ThesisThesis fully internal (DIV)

    593 Downloads (Pure)

    Abstract

    Treating heart failure is one of the greatest unmet needs in cardiovascular medicine today. Overall survival is poor and 50% of patients die within 5 years of their initial diagnosis. Heart failure is a heterogeneous syndrome and a one-size-fits-all approach is ineffective. Therefore, in my thesis I used biomarkers to 1. Show that patients with heart failure and a preserved ejection fraction are subject to more inflammation, which can be a key treatment target and 2. Identified clinical relevant subgroups with differences in response to treatment using machine learning based approaches.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • van der Meer, Peter, Supervisor
    • Voors, Adriaan, Supervisor
    • Brunner-La Rocca, Hans-Peter, Assessment committee, External person
    • van Gilst, Wiek, Assessment committee
    Award date17-Sep-2018
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-1064-7
    Electronic ISBNs978-94-034-1063-0
    Publication statusPublished - 2018

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