Abstract
The invention relates to biomarkers and uses thereof, in particular to a set of proteins or mRNAs that provides a significant indication as to whether a cell is senescent or not. Provided is the use of a biomarker panel comprising six or more polypeptides, or their encoding mRNA's, wherein the panel comprises at least the biomarkers TSPAN13, GDNF, C2CD5, SUSD6, BCL2L2, PLK3, or a variant or fragment thereof, as a biomarker set for cellular senescence. Also provided is a senescent cell detection kit for detecting senescent cells, and a drug conjugate for killing a senescent cell.
| Original language | English |
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| Patent number | WO2018164580 |
| Priority date | 09/03/2017 |
| Publication status | Published - 13-Sep-2018 |