Biomedical Applications of Nanodiamonds in Microbiology

Neda Norouzi

    Research output: ThesisThesis fully internal (DIV)

    548 Downloads (Pure)

    Abstract

    The studies in this dissertation represent stepping stones toward the potential applications of nanodiamonds in a microbiological environment. The usefulness of Fluorescent Nanodiamonds(FNDs) as sensors for detecting free radical species in bacteria and Detonation Nanodiamonds(DNDs) potential as antibactericidal coating have been considered in this thesis. FNDs reveal no antibacterial effect in the concentration range relevant for biosensing applications. Reduction of colony formation of S. aureus due to interaction with nanodiamonds does not result from toxicity, but aggregation. Nanodiamonds can be introduced as a tool to measure free radicals in live organisms and microorganisms including bacteria. T1 measurements reveal the magnetic noise of free radical existence surrounding the NV- center. Relaxometry allows us to measure the dynamic of free radical generation in real-time. Relaxometry has proven its advantages but there is room for improvement. Mechanically or chemically engineering of surface properties of black silicon or black Diamond is a promising approach to directly repel bacteria.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Schirhagl, Romana, Supervisor
    • Najafi, Mohammad B. Habibi, Supervisor, External person
    Award date23-Nov-2022
    Place of Publication[Groningen]
    Publisher
    DOIs
    Publication statusPublished - 2022

    Fingerprint

    Dive into the research topics of 'Biomedical Applications of Nanodiamonds in Microbiology'. Together they form a unique fingerprint.

    Cite this