Biomimetic drug nanocarriers to overcome biological barriers: Inspiration from pathogen invasion

Cuifeng Wang

    Research output: ThesisThesis fully internal (DIV)

    289 Downloads (Pure)

    Abstract

    Biological barriers including skin, mucosal membranes, blood brain barrier as well as cell and nuclear membrane serve the natural protective function in the body, they limit delivery of drugs into the body. However, several pathogens could exploit physiological pathways to overcome extracellular and intracellular barriers for their infection. Based on the molecular mechanism involved in pathogenic invasion, several bimimetic nanoparticles have been designed for drug delivery to overcome the barriers, i.e. the intestinal barrier, the blood-brain barrier, and the endosomal barrier in vitro.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Hoekstra, Dick, Supervisor
    • Zuhorn, Inge, Co-supervisor
    • Kampinga, Harrie, Assessment committee
    • Haisma, Hidde, Assessment committee
    • Hennink, W.E, Assessment committee, External person
    Award date15-Feb-2016
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-6203-986-5
    Electronic ISBNs978-90-367-8659-1
    Publication statusPublished - 2016

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