Biological barriers including skin, mucosal membranes, blood brain barrier as well as cell and nuclear membrane serve the natural protective function in the body, they limit delivery of drugs into the body. However, several pathogens could exploit physiological pathways to overcome extracellular and intracellular barriers for their infection. Based on the molecular mechanism involved in pathogenic invasion, several bimimetic nanoparticles have been designed for drug delivery to overcome the barriers, i.e. the intestinal barrier, the blood-brain barrier, and the endosomal barrier in vitro.
|Qualification||Doctor of Philosophy|
|Place of Publication||[Groningen]|
|Publication status||Published - 2016|