Biosensor comprising waveguide

Johannes Joseph Hubertina Barbara Schleipen; Reinhold Wimberger-Friedl; Pieter Jan van der Zaag; Hendrik Paul Urbach; Mitradeep Sarkar

Biosensor comprising waveguide

Johannes Joseph Hubertina Barbara Schleipen (Inventor), Reinhold Wimberger-Friedl (Inventor), Pieter Jan van der Zaag (Inventor), Hendrik Paul Urbach (Inventor), Mitradeep Sarkar (Inventor)

Molecular Biophysics

Research output: Patent

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Abstract

The invention relates to an optical device (110) and a corresponding detection apparatus (100) that may for example be used for monitoring the replication of nucleotide sequences at a surface. In a preferred embodiment, the optical device (110) comprises a waveguide substrate (130) with a wiregrid (140) on a bottom surface (132), wherein apertures (141) of the wiregrid are in at least one direction (x) smaller than a characteristic wavelength (λ) of input light (IL). Moreover, a diffractive structure (120) is disposed on the opposite surface (131) of the substrate (130) for coupling input light (IL) into the substrate (130) such that constructive interference occurs at the apertures (141). Thus evanescent waves can be generated with high efficiency in these apertures, allowing for example for a surface-specific excitation of fluorescence (FL) that can be sensed by a detector (160).

Original language	English
Patent number	WO2015082247
Priority date	03/12/2013
Filing date	25/11/2014
Publication status	Published - 11-Jun-2015

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title = "Biosensor comprising waveguide",

abstract = "The invention relates to an optical device (110) and a corresponding detection apparatus (100) that may for example be used for monitoring the replication of nucleotide sequences at a surface. In a preferred embodiment, the optical device (110) comprises a waveguide substrate (130) with a wiregrid (140) on a bottom surface (132), wherein apertures (141) of the wiregrid are in at least one direction (x) smaller than a characteristic wavelength (λ) of input light (IL). Moreover, a diffractive structure (120) is disposed on the opposite surface (131) of the substrate (130) for coupling input light (IL) into the substrate (130) such that constructive interference occurs at the apertures (141). Thus evanescent waves can be generated with high efficiency in these apertures, allowing for example for a surface-specific excitation of fluorescence (FL) that can be sensed by a detector (160).",

author = "Schleipen, {Johannes Joseph Hubertina Barbara} and Reinhold Wimberger-Friedl and {van der Zaag}, {Pieter Jan} and Urbach, {Hendrik Paul} and Mitradeep Sarkar",

year = "2015",

month = jun,

day = "11",

language = "English",

type = "Patent",

note = "WO2015082247",

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TY - PAT

T1 - Biosensor comprising waveguide

AU - Schleipen, Johannes Joseph Hubertina Barbara

AU - Wimberger-Friedl, Reinhold

AU - van der Zaag, Pieter Jan

AU - Urbach, Hendrik Paul

AU - Sarkar, Mitradeep

PY - 2015/6/11

Y1 - 2015/6/11

N2 - The invention relates to an optical device (110) and a corresponding detection apparatus (100) that may for example be used for monitoring the replication of nucleotide sequences at a surface. In a preferred embodiment, the optical device (110) comprises a waveguide substrate (130) with a wiregrid (140) on a bottom surface (132), wherein apertures (141) of the wiregrid are in at least one direction (x) smaller than a characteristic wavelength (λ) of input light (IL). Moreover, a diffractive structure (120) is disposed on the opposite surface (131) of the substrate (130) for coupling input light (IL) into the substrate (130) such that constructive interference occurs at the apertures (141). Thus evanescent waves can be generated with high efficiency in these apertures, allowing for example for a surface-specific excitation of fluorescence (FL) that can be sensed by a detector (160).

AB - The invention relates to an optical device (110) and a corresponding detection apparatus (100) that may for example be used for monitoring the replication of nucleotide sequences at a surface. In a preferred embodiment, the optical device (110) comprises a waveguide substrate (130) with a wiregrid (140) on a bottom surface (132), wherein apertures (141) of the wiregrid are in at least one direction (x) smaller than a characteristic wavelength (λ) of input light (IL). Moreover, a diffractive structure (120) is disposed on the opposite surface (131) of the substrate (130) for coupling input light (IL) into the substrate (130) such that constructive interference occurs at the apertures (141). Thus evanescent waves can be generated with high efficiency in these apertures, allowing for example for a surface-specific excitation of fluorescence (FL) that can be sensed by a detector (160).

M3 - Patent

M1 - WO2015082247

Y2 - 2014/11/25

ER -

Biosensor comprising waveguide

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