Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding

Yvonne V. Sanders; Karin Fijnvandraat; Johan Boender; Evelien P. Mauser-Bunschoten; Johanna G. van der Bom; Joke de Meris; Frans J. Smiers; Bernd Granzen; Paul Brons; Rienk Y. J. Tamminga; Marjon H. Cnossen; Frank W. G. Leebeek; WiN Study Grp

doi:10.1002/ajh.24195

Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding

Yvonne V. Sanders, Karin Fijnvandraat, Johan Boender, Evelien P. Mauser-Bunschoten, Johanna G. van der Bom, Joke de Meris, Frans J. Smiers, Bernd Granzen, Paul Brons, Rienk Y. J. Tamminga, Marjon H. Cnossen, Frank W. G. Leebeek^*, WiN Study Grp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

52 Citations (Scopus)

Abstract

The bleeding phenotype of children with von Willebrand disease (VWD) needs to be characterized in detail to facilitate diagnosis during childhood and aid in the planning and assessment of treatment strategies. The objective was to evaluate the occurrence, type, and severity of bleeding in a large cohort of children with moderate and severe VWD. We included 113 children (aged 0-16 years) with Type 1 (n=60), 2 (n=44), and 3 (n=9) VWD with von Willebrand factor (VWF) antigen and/or VWF ristocetin cofactor levels

Original language	English
Pages (from-to)	1142-1148
Number of pages	7
Journal	American Journal of Hematology
Volume	90
Issue number	12
DOIs	https://doi.org/10.1002/ajh.24195
Publication status	Published - Dec-2015

Keywords

ASSESSMENT-TOOL
ADULT PATIENTS
QUESTIONNAIRE
DIAGNOSIS
PREVALENCE
DISORDERS
MANAGEMENT
SYMPTOMS
SCORE
VWD

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Sanders, Y. V., Fijnvandraat, K., Boender, J., Mauser-Bunschoten, E. P., van der Bom, J. G., de Meris, J., Smiers, F. J., Granzen, B., Brons, P., Tamminga, R. Y. J., Cnossen, M. H., Leebeek, F. W. G., & WiN Study Grp (2015). Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding. American Journal of Hematology, 90(12), 1142-1148. https://doi.org/10.1002/ajh.24195

@article{c0eb87d7f9454525a5bd850418c2e705,

title = "Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding",

abstract = "The bleeding phenotype of children with von Willebrand disease (VWD) needs to be characterized in detail to facilitate diagnosis during childhood and aid in the planning and assessment of treatment strategies. The objective was to evaluate the occurrence, type, and severity of bleeding in a large cohort of children with moderate and severe VWD. We included 113 children (aged 0-16 years) with Type 1 (n=60), 2 (n=44), and 3 (n=9) VWD with von Willebrand factor (VWF) antigen and/or VWF ristocetin cofactor levels",

keywords = "ASSESSMENT-TOOL, ADULT PATIENTS, QUESTIONNAIRE, DIAGNOSIS, PREVALENCE, DISORDERS, MANAGEMENT, SYMPTOMS, SCORE, VWD",

author = "Sanders, {Yvonne V.} and Karin Fijnvandraat and Johan Boender and Mauser-Bunschoten, {Evelien P.} and {van der Bom}, {Johanna G.} and {de Meris}, Joke and Smiers, {Frans J.} and Bernd Granzen and Paul Brons and Tamminga, {Rienk Y. J.} and Cnossen, {Marjon H.} and Leebeek, {Frank W. G.} and {WiN Study Grp}",

year = "2015",

month = dec,

doi = "10.1002/ajh.24195",

language = "English",

volume = "90",

pages = "1142--1148",

journal = "American Journal of Hematology",

issn = "0361-8609",

publisher = "Wiley",

number = "12",

}

Sanders, YV, Fijnvandraat, K, Boender, J, Mauser-Bunschoten, EP, van der Bom, JG, de Meris, J, Smiers, FJ, Granzen, B, Brons, P, Tamminga, RYJ, Cnossen, MH, Leebeek, FWG & WiN Study Grp 2015, 'Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding', American Journal of Hematology, vol. 90, no. 12, pp. 1142-1148. https://doi.org/10.1002/ajh.24195

TY - JOUR

T1 - Bleeding spectrum in children with moderate or severe von Willebrand disease

T2 - Relevance of pediatric-specific bleeding

AU - Sanders, Yvonne V.

AU - Fijnvandraat, Karin

AU - Boender, Johan

AU - Mauser-Bunschoten, Evelien P.

AU - van der Bom, Johanna G.

AU - de Meris, Joke

AU - Smiers, Frans J.

AU - Granzen, Bernd

AU - Brons, Paul

AU - Tamminga, Rienk Y. J.

AU - Cnossen, Marjon H.

AU - Leebeek, Frank W. G.

AU - WiN Study Grp

PY - 2015/12

Y1 - 2015/12

N2 - The bleeding phenotype of children with von Willebrand disease (VWD) needs to be characterized in detail to facilitate diagnosis during childhood and aid in the planning and assessment of treatment strategies. The objective was to evaluate the occurrence, type, and severity of bleeding in a large cohort of children with moderate and severe VWD. We included 113 children (aged 0-16 years) with Type 1 (n=60), 2 (n=44), and 3 (n=9) VWD with von Willebrand factor (VWF) antigen and/or VWF ristocetin cofactor levels

AB - The bleeding phenotype of children with von Willebrand disease (VWD) needs to be characterized in detail to facilitate diagnosis during childhood and aid in the planning and assessment of treatment strategies. The objective was to evaluate the occurrence, type, and severity of bleeding in a large cohort of children with moderate and severe VWD. We included 113 children (aged 0-16 years) with Type 1 (n=60), 2 (n=44), and 3 (n=9) VWD with von Willebrand factor (VWF) antigen and/or VWF ristocetin cofactor levels

KW - ASSESSMENT-TOOL

KW - ADULT PATIENTS

KW - QUESTIONNAIRE

KW - DIAGNOSIS

KW - PREVALENCE

KW - DISORDERS

KW - MANAGEMENT

KW - SYMPTOMS

KW - SCORE

KW - VWD

U2 - 10.1002/ajh.24195

DO - 10.1002/ajh.24195

M3 - Article

SN - 0361-8609

VL - 90

SP - 1142

EP - 1148

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 12

ER -

Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding

Abstract

Keywords

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