Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer: A prospective cohort study

Jannet C Beukema; Jan-Willem Haveman; Johannes A Langendijk; Edwin Oldehinkel; Alphons C M van den Bergh; Jacco J de Haan; Joost P van Melle; Peter van Luijk; Christina T Muijs

doi:10.1016/j.radonc.2024.110479

Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer: A prospective cohort study

Jannet C Beukema^*, Jan-Willem Haveman, Johannes A Langendijk, Edwin Oldehinkel, Alphons C M van den Bergh, Jacco J de Haan, Joost P van Melle, Peter van Luijk, Christina T Muijs

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

PURPOSE: The aim of this study was to test the hypothesis that the levels of High Sensitive Troponin T (HS-TNT) and N-terminal Brain Natriuretic Peptide (NT-ProBNP) increase after radiation therapy in a dose dependent way and are predictive for clinical cardiac events.

MATERIALS AND METHODS: Blood samples during and after radiotherapy of 87 esophageal cancer patients were analysed regarding the course of HS-TNT and NT-ProBNP levels and their relationship with clinical toxicity endpoints and radiation dose volume parameters.

RESULTS: HS-TNT values at the end of treatment correlated with the mean heart dose (p = 0.02), whereas the rise of NT-ProBNP correlated with the mean lung dose (p = 0.01). Furthermore, the course of both HS-TNT (p < 0.001) and NT-ProBNP (p < 0.01) levels were significantly different for patients who developed new cardiac events as opposed to those without new cardiac events.

CONCLUSION: Significant correlations were found for both biomarkers with radiation dose and clinical toxicity endpoints after treatment. Therefore, these markers might be of additional value in NTCP models for cardiac events and might help us unravelling the mechanisms behind these toxicity endpoints.

Original language	English
Article number	110479
Number of pages	7
Journal	Radiotherapy and Oncology
Volume	200
Early online date	18-Aug-2024
DOIs	https://doi.org/10.1016/j.radonc.2024.110479
Publication status	Published - Nov-2024

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Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancerFinal publisher's version, 1.23 MBLicence: CC BY

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Beukema, J. C., Haveman, J.-W., Langendijk, J. A., Oldehinkel, E., van den Bergh, A. C. M., de Haan, J. J., van Melle, J. P., van Luijk, P., & Muijs, C. T. (2024). Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer: A prospective cohort study. Radiotherapy and Oncology, 200, Article 110479. https://doi.org/10.1016/j.radonc.2024.110479

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title = "Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer: A prospective cohort study",

abstract = "PURPOSE: The aim of this study was to test the hypothesis that the levels of High Sensitive Troponin T (HS-TNT) and N-terminal Brain Natriuretic Peptide (NT-ProBNP) increase after radiation therapy in a dose dependent way and are predictive for clinical cardiac events.MATERIALS AND METHODS: Blood samples during and after radiotherapy of 87 esophageal cancer patients were analysed regarding the course of HS-TNT and NT-ProBNP levels and their relationship with clinical toxicity endpoints and radiation dose volume parameters.RESULTS: HS-TNT values at the end of treatment correlated with the mean heart dose (p = 0.02), whereas the rise of NT-ProBNP correlated with the mean lung dose (p = 0.01). Furthermore, the course of both HS-TNT (p < 0.001) and NT-ProBNP (p < 0.01) levels were significantly different for patients who developed new cardiac events as opposed to those without new cardiac events.CONCLUSION: Significant correlations were found for both biomarkers with radiation dose and clinical toxicity endpoints after treatment. Therefore, these markers might be of additional value in NTCP models for cardiac events and might help us unravelling the mechanisms behind these toxicity endpoints.",

author = "Beukema, {Jannet C} and Jan-Willem Haveman and Langendijk, {Johannes A} and Edwin Oldehinkel and {van den Bergh}, {Alphons C M} and {de Haan}, {Jacco J} and {van Melle}, {Joost P} and {van Luijk}, Peter and Muijs, {Christina T}",

year = "2024",

month = nov,

doi = "10.1016/j.radonc.2024.110479",

language = "English",

volume = "200",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

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}

TY - JOUR

T1 - Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer

T2 - A prospective cohort study

AU - Beukema, Jannet C

AU - Haveman, Jan-Willem

AU - Langendijk, Johannes A

AU - Oldehinkel, Edwin

AU - van den Bergh, Alphons C M

AU - de Haan, Jacco J

AU - van Melle, Joost P

AU - van Luijk, Peter

AU - Muijs, Christina T

PY - 2024/11

Y1 - 2024/11

N2 - PURPOSE: The aim of this study was to test the hypothesis that the levels of High Sensitive Troponin T (HS-TNT) and N-terminal Brain Natriuretic Peptide (NT-ProBNP) increase after radiation therapy in a dose dependent way and are predictive for clinical cardiac events.MATERIALS AND METHODS: Blood samples during and after radiotherapy of 87 esophageal cancer patients were analysed regarding the course of HS-TNT and NT-ProBNP levels and their relationship with clinical toxicity endpoints and radiation dose volume parameters.RESULTS: HS-TNT values at the end of treatment correlated with the mean heart dose (p = 0.02), whereas the rise of NT-ProBNP correlated with the mean lung dose (p = 0.01). Furthermore, the course of both HS-TNT (p < 0.001) and NT-ProBNP (p < 0.01) levels were significantly different for patients who developed new cardiac events as opposed to those without new cardiac events.CONCLUSION: Significant correlations were found for both biomarkers with radiation dose and clinical toxicity endpoints after treatment. Therefore, these markers might be of additional value in NTCP models for cardiac events and might help us unravelling the mechanisms behind these toxicity endpoints.

AB - PURPOSE: The aim of this study was to test the hypothesis that the levels of High Sensitive Troponin T (HS-TNT) and N-terminal Brain Natriuretic Peptide (NT-ProBNP) increase after radiation therapy in a dose dependent way and are predictive for clinical cardiac events.MATERIALS AND METHODS: Blood samples during and after radiotherapy of 87 esophageal cancer patients were analysed regarding the course of HS-TNT and NT-ProBNP levels and their relationship with clinical toxicity endpoints and radiation dose volume parameters.RESULTS: HS-TNT values at the end of treatment correlated with the mean heart dose (p = 0.02), whereas the rise of NT-ProBNP correlated with the mean lung dose (p = 0.01). Furthermore, the course of both HS-TNT (p < 0.001) and NT-ProBNP (p < 0.01) levels were significantly different for patients who developed new cardiac events as opposed to those without new cardiac events.CONCLUSION: Significant correlations were found for both biomarkers with radiation dose and clinical toxicity endpoints after treatment. Therefore, these markers might be of additional value in NTCP models for cardiac events and might help us unravelling the mechanisms behind these toxicity endpoints.

U2 - 10.1016/j.radonc.2024.110479

DO - 10.1016/j.radonc.2024.110479

M3 - Article

C2 - 39154840

SN - 0167-8140

VL - 200

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

M1 - 110479

ER -

Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer: A prospective cohort study

Abstract

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