Blood Markers of Portal Hypertension Are Associated with Blood Loss and Transfusion Requirements during Orthotopic Liver Transplantation

Freeha Arshad, Ton Lisman*, Robert J. Porte

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

There is increasing evidence that portal hypertension plays a major role in bleeding risk during orthotopic liver transplantation (OLT). We investigated the association between preoperative blood levels of von Willebrand factor (VWF) and soluble CD163 (sCD163), which are established markers of portal hypertension, and blood loss and transfusion requirements during OLT. We measured levels of VWF and sCD163 in preoperative serum samples of 168 adult patients undergoing a primary OLT between 1998 and 2012. Preoperative levels of VWF and sCD163 correlated with the model of end-stage liver disease (MELD) score ( r =0.414, p

Original languageEnglish
Pages (from-to)751-756
Number of pages6
JournalSeminars in thrombosis and hemostasis
Volume46
Issue number6
DOIs
Publication statusPublished - Sep-2020

Keywords

  • cirrhosis
  • red blood cell
  • von Willebrand factor
  • CD163
  • bleeding
  • VON-WILLEBRAND-FACTOR
  • THROMBIN GENERATION
  • INTRAOPERATIVE CHANGES
  • COAGULATION
  • MORTALITY
  • SURVIVAL
  • DISEASE

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