Blood pressure and anthropometrics of 4-y-old children born after preimplantation genetic screening: follow-up of a unique, moderately sized, randomized controlled trial

Jorien Seggers, Maaike L. Haadsma, Sacha la Bastide-van Gemert, Maas Jan Heineman, Joke H. Kok, Karin J. Middelburg, Tessa J. Roseboom, Pamela Schendelaar, Edwin R. Van den Heuvel, Mijna Hadders-Algra*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

BACKGROUND: Recent studies suggest that in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with suboptimal cardiometabolic outcome in offspring. It is unknown whether preimplantation genetic screening (PGS), which involves embryo biopsy, affects blood pressure (BP), anthropometrics, and the frequency of received medical care.

METHODS: In this prospective multicenter follow-up study, we assessed BP, anthropometrics, and received medical care of 4-y-old children born to women who were randomly assigned to IVF/ICSI with PGS (n = 49) or without PGS (controls; n = 64). We applied linear and generalized linear mixed-effects models to investigate possible effects of PGS.

RESULTS: BP in the PGS and control groups was similar: 102/64 and 100/64 mm Hg, respectively. Main anthropometric outcomes in the PGS vs. control group were: BMI: 16.1 vs. 15.8; triceps skinfold: 108 vs. 98 mm; and subscapular skinfold: 54 vs. 53 mm (all P values > 0.05). More PGS children than controls had received paramedical care (speech, physical, or occupational therapy: 14 (29%) vs. 9 (14%); P = 0.03 in multivariable analysis). The frequency of medicial treatment was comparable.

CONCLUSION: PGS does not seem to affect BP or anthropometrics in 4-y-old children. The higher frequency of received paramedical care after PGS may suggest an effect of PGS on subtle developmental parameters.

Original languageEnglish
Pages (from-to)606-614
Number of pages9
JournalPediatric Research
Volume74
Issue number5
DOIs
Publication statusPublished - Nov-2013

Keywords

  • IN-VITRO FERTILIZATION
  • CORONARY HEART-DISEASE
  • MATERNAL UNDERNUTRITION
  • LATER LIFE
  • DIAGNOSIS
  • ADOLESCENTS
  • TECHNOLOGY
  • ENVIRONMENT
  • ADIPOSITY
  • EMBRYO

Cite this