Blood pressure decreases more after high-carbohydrate meals than after high-protein meals in overweight adults with elevated blood pressure, but there is no difference after 4 weeks of consuming a carbohydrate-rich or protein-rich diet

Karianna F. M. Teunissen-Beekman*, Janneke Dopheide, Johanna M. Geleijnse, Stephan J. L. Bakker, Elizabeth J. Brink, Peter W. de Leeuw, Jan Serroyen, Marleen A. van Baak

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

The replacement of dietary carbohydrates with proteins can lower blood pressure (BP), but the mechanisms remain unclear. This randomized, double-blind, parallel-group study aimed to compare 12-h postprandial sympathetic and hemodynamic responses after high-protein (HP) meals and high-carbohydrate (HO) meals. Fifty-two men and women with untreated elevated BP were tested on d 1 and after 4 wk of supplementation [3 x 20 g protein (HP) or maltodextrin (HC) per day]. No between-group differences were found in postprandial plasma norepinephrine on d 1 and at wk 4. On d 1, postprandial mean arterial pressure (MAP) decreased more in the HC group than in the HP group (P = 0.002). This difference was not present at 4 wk, because the postprandial decline in MAP tended to become larger in the HP group after 4 wk of supplementation (P = 0.07). On both test days, postprandial total peripheral resistance tended to decrease more in the HO group (P <0.08). After 4 wk of supplementation, cardiac output tended to increase more in the HO group (P = 0.08). In conclusion, ingestion of an HP diet induced a smaller decrease in BP on d 1 than did ingestion of an HC diet. This difference disappeared after 4 wk due to a more pronounced decrease in BP in the HP group after 4 wk than on d 1. These findings cannot explain the BP-lowering effect ascribed to dietary proteins. J. Nutr. 143: 424-429, 2013.

Original languageEnglish
Pages (from-to)424-429
Number of pages6
JournalJournal of Nutrition
Volume143
Issue number4
DOIs
Publication statusPublished - Apr-2013

Keywords

  • SYSTEMIC HEMODYNAMIC-CHANGES
  • RANDOMIZED-TRIAL
  • SYMPATHETIC ACTIVITY
  • ELDERLY SUBJECTS
  • HUMANS
  • INSULIN
  • ACTIVATION
  • INGESTION
  • HORMONE
  • GLUCOSE

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