TY - JOUR
T1 - Body temperature and mood variations during forced desynchronization in winter expression
T2 - A preliminary report
AU - Koorengevel, Kathelijne M.
AU - Beersma, Domien G.M.
AU - Gordijn, Marijke C.M.
AU - den Boer, Johan
AU - van den Hoofdakker, Rutger H.
N1 - Relation: http://www.rug.nl/fwn/onderzoek/programmas/cbn/index
Rights: University of Groningen, Centre for Behaviour and Neurosciences
PY - 2000/2/15
Y1 - 2000/2/15
N2 - Background: It has been suggested that certain abnormalities (e.g., in phase or amplitude) of the circadian pacemaker underlie seasonal affective disorder,Methods: One male seasonal affective disorder patient (blind to the study: design) participated in two 120-hour forced desynchrony experiments and tvas subjected to six 20-hour days, once during a depressive episode and once after recovery. Core body temperature was continuously measured. During wakefulness, the Adjective Mood Scale was completed at 2-hour intervals,Results: Sleep-wake as well as pacemaker-related variations of mood were found, both when the subject was depressed and when he was euthymic. Compared with recovery, during the depressive episode the circadian temperature minimum and the circadian mood variation showed phase delays of approximately 1 and 2 hours, respectively.Conclusions: The data of this first seasonal affective disorder patient, participating in forced desynchrony experiments, malt indicate a phase delay of the circadian pacemaker during a seasonal affective disorder episode, Biol Psychiatry 2000;47:355-358 (C) 2000 Society of Biological Psychiatry.
AB - Background: It has been suggested that certain abnormalities (e.g., in phase or amplitude) of the circadian pacemaker underlie seasonal affective disorder,Methods: One male seasonal affective disorder patient (blind to the study: design) participated in two 120-hour forced desynchrony experiments and tvas subjected to six 20-hour days, once during a depressive episode and once after recovery. Core body temperature was continuously measured. During wakefulness, the Adjective Mood Scale was completed at 2-hour intervals,Results: Sleep-wake as well as pacemaker-related variations of mood were found, both when the subject was depressed and when he was euthymic. Compared with recovery, during the depressive episode the circadian temperature minimum and the circadian mood variation showed phase delays of approximately 1 and 2 hours, respectively.Conclusions: The data of this first seasonal affective disorder patient, participating in forced desynchrony experiments, malt indicate a phase delay of the circadian pacemaker during a seasonal affective disorder episode, Biol Psychiatry 2000;47:355-358 (C) 2000 Society of Biological Psychiatry.
KW - seasonal affective disorder
KW - mood
KW - circadian rhythms
KW - phase shift
KW - forced desynchronization
KW - light therapy
KW - SEASONAL AFFECTIVE-DISORDER
KW - CONSTANT ROUTINE
U2 - 10.1016/S0006-3223(99)00225-5
DO - 10.1016/S0006-3223(99)00225-5
M3 - Article
SN - 1873-2402
VL - 47
SP - 355
EP - 358
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 4
ER -