Body temperature predicts the direction of internal desynchronization in humans isolated from time cues

Serge Daan*, Sato Honma, Ken-ichi Honma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
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Abstract

This publication presents a new analysis of experiments that were carried out in human subjects in isolation from time cues, under supervision of Jurgen Aschoff and Rutger Wever at the Max Planck Institute for Behavioural Physiology (Erling-Andechs, Germany, 1964-1974). Mean rectal temperatures (t(b)) were compared between subjects who showed internal desynchronization (ID) and internal synchronization (IS) of the endogenous rhythms of sleep-wakefulness and of body temperature. The results showed that t(b) was reduced in long ID (circadian sleep-wake cycle length [(SW)] > 27 h) and increased in short ID ((SW) <22 h) relative to IS. In subjects with both ID and IS sections in the complete record, these differences were also found when comparing only the IS sections: Low t(b) during IS predicts the later occurrence of long ID, and high t(b) predicts the incidence of short ID. While this association is associated with sex differences in t(b), it also occurs within each sex. To the extent that the variation in t(b) reflects the variation in heat production (metabolic rate), the results are consistent with the proposition that the spontaneous frequency of the human sleep-wake oscillator is associated with the metabolic rate, as suggested on the basis of the proportionality of meal frequency and sleep-wake frequency. The finding thus has implications for our views on spontaneous sleep timing.

Original languageEnglish
Pages (from-to)403-411
Number of pages9
JournalJournal of Biological Rhythms
Volume28
Issue number6
DOIs
Publication statusPublished - Dec-2013

Keywords

  • human sleep-wake rhythm
  • circadian
  • internal desynchronization
  • sex differences
  • body temperature
  • metabolic rate
  • SLEEP-WAKE CYCLE
  • HUMAN CIRCADIAN-RHYTHMS
  • MUTANT SYRIAN-HAMSTERS
  • TEMPORAL ISOLATION
  • SEX-DIFFERENCES
  • HEART-RATE
  • METABOLISM
  • CLOCKS
  • MEN
  • FREQUENCY

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