Body weight course in the DIAbetes and LifEstyle Cohort Twente (DIALECT-1)-A 20-year observational study

Christina M. Gant*, Ijmke Mensink, S. Heleen Binnenmars, Job A. M. van der Palen, Stephan J. L. Bakker, Gerjan Navis, Gozewijn D. Laverman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
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Abstract

Background

Although weight gain increases risk of type 2 diabetes, real-life data on the weight course in patients with established type 2 diabetes are scarce. We assessed weight course in a real-life diabetes secondary care setting and analyzed its association with patient characteristics, lifestyle habits and initiation of insulin, glucagon like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose co-transporter-2 inhibitors (SGLT-2i).

Methods

Data on weight, insulin, GLP-1 RA and SGLT-2i use were collected retrospectively (12 years) and prospectively (8 years) from patients included in the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1, n = 450, age 63 +/- 9 years, 58% men, diabetes duration [7-18] years). Lifestyle habits were assessed using validated questionnaires. The association of clinical parameters with body mass index (BMI) course was determined using linear mixed models. Patients who underwent bariatric surgery (n = 19) had a distinct BMI course and were excluded from the study.

Results

Baseline BMI was 31.3 (0.3) and was higher in women, patients aged

Conclusions

High BMI that real-life patients with type 2 diabetes gained earlier in life, remained stable in the following decades. Weight loss interventions should remain a priority, and GLP-1 RA might be considered to support weight loss.

Original languageEnglish
Article number0218400
Number of pages14
JournalPLoS ONE
Volume14
Issue number6
DOIs
Publication statusPublished - 19-Jun-2019

Keywords

  • FAT MASS
  • TYPE-2
  • INTERVENTIONS
  • GAIN
  • AGE
  • QUESTIONNAIRE
  • ASSOCIATIONS
  • METAANALYSIS
  • VALIDITY
  • OUTCOMES

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