Body weight course in the DIAbetes and LifEstyle Cohort Twente (DIALECT-1)-A 20-year observational study

Christina M. Gant; Ijmke Mensink; S. Heleen Binnenmars; Job A. M. van der Palen; Stephan J. L. Bakker; Gerjan Navis; Gozewijn D. Laverman

doi:10.1371/journal.pone.0218400

Body weight course in the DIAbetes and LifEstyle Cohort Twente (DIALECT-1)-A 20-year observational study

Christina M. Gant^*, Ijmke Mensink, S. Heleen Binnenmars, Job A. M. van der Palen, Stephan J. L. Bakker, Gerjan Navis, Gozewijn D. Laverman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

146 Downloads (Pure)

Abstract

Background

Although weight gain increases risk of type 2 diabetes, real-life data on the weight course in patients with established type 2 diabetes are scarce. We assessed weight course in a real-life diabetes secondary care setting and analyzed its association with patient characteristics, lifestyle habits and initiation of insulin, glucagon like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose co-transporter-2 inhibitors (SGLT-2i).

Methods

Data on weight, insulin, GLP-1 RA and SGLT-2i use were collected retrospectively (12 years) and prospectively (8 years) from patients included in the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1, n = 450, age 63 +/- 9 years, 58% men, diabetes duration [7-18] years). Lifestyle habits were assessed using validated questionnaires. The association of clinical parameters with body mass index (BMI) course was determined using linear mixed models. Patients who underwent bariatric surgery (n = 19) had a distinct BMI course and were excluded from the study.

Results

Baseline BMI was 31.3 (0.3) and was higher in women, patients aged

Conclusions

High BMI that real-life patients with type 2 diabetes gained earlier in life, remained stable in the following decades. Weight loss interventions should remain a priority, and GLP-1 RA might be considered to support weight loss.

Original language	English
Article number	0218400
Number of pages	14
Journal	PLoS ONE
Volume	14
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0218400
Publication status	Published - 19-Jun-2019

Keywords

FAT MASS
TYPE-2
INTERVENTIONS
GAIN
AGE
QUESTIONNAIRE
ASSOCIATIONS
METAANALYSIS
VALIDITY
OUTCOMES

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Body weight course in the DIAbetes and LifEstyle Cohort Twente (DIALECT-1)—A 20-year observational studyFinal publisher's version, 495 KBLicence: CC BY

Cite this

@article{768c7fe957024305992a75cf81b41bb1,

title = "Body weight course in the DIAbetes and LifEstyle Cohort Twente (DIALECT-1)-A 20-year observational study",

abstract = "BackgroundAlthough weight gain increases risk of type 2 diabetes, real-life data on the weight course in patients with established type 2 diabetes are scarce. We assessed weight course in a real-life diabetes secondary care setting and analyzed its association with patient characteristics, lifestyle habits and initiation of insulin, glucagon like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose co-transporter-2 inhibitors (SGLT-2i).MethodsData on weight, insulin, GLP-1 RA and SGLT-2i use were collected retrospectively (12 years) and prospectively (8 years) from patients included in the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1, n = 450, age 63 +/- 9 years, 58% men, diabetes duration [7-18] years). Lifestyle habits were assessed using validated questionnaires. The association of clinical parameters with body mass index (BMI) course was determined using linear mixed models. Patients who underwent bariatric surgery (n = 19) had a distinct BMI course and were excluded from the study.ResultsBaseline BMI was 31.3 (0.3) and was higher in women, patients agedConclusionsHigh BMI that real-life patients with type 2 diabetes gained earlier in life, remained stable in the following decades. Weight loss interventions should remain a priority, and GLP-1 RA might be considered to support weight loss.",

keywords = "FAT MASS, TYPE-2, INTERVENTIONS, GAIN, AGE, QUESTIONNAIRE, ASSOCIATIONS, METAANALYSIS, VALIDITY, OUTCOMES",

author = "Gant, {Christina M.} and Ijmke Mensink and Binnenmars, {S. Heleen} and {van der Palen}, {Job A. M.} and Bakker, {Stephan J. L.} and Gerjan Navis and Laverman, {Gozewijn D.}",

year = "2019",

month = jun,

day = "19",

doi = "10.1371/journal.pone.0218400",

language = "English",

volume = "14",

journal = "PLOS-One",

issn = "1932-6203",

publisher = "PUBLIC LIBRARY SCIENCE",

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Body weight course in the DIAbetes and LifEstyle Cohort Twente (DIALECT-1)-A 20-year observational study. / Gant, Christina M.; Mensink, Ijmke; Binnenmars, S. Heleen; van der Palen, Job A. M.; Bakker, Stephan J. L.; Navis, Gerjan; Laverman, Gozewijn D.

In: PLoS ONE, Vol. 14, No. 6, 0218400, 19.06.2019.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Body weight course in the DIAbetes and LifEstyle Cohort Twente (DIALECT-1)-A 20-year observational study

AU - Gant, Christina M.

AU - Mensink, Ijmke

AU - Binnenmars, S. Heleen

AU - van der Palen, Job A. M.

AU - Bakker, Stephan J. L.

AU - Navis, Gerjan

AU - Laverman, Gozewijn D.

PY - 2019/6/19

Y1 - 2019/6/19

N2 - BackgroundAlthough weight gain increases risk of type 2 diabetes, real-life data on the weight course in patients with established type 2 diabetes are scarce. We assessed weight course in a real-life diabetes secondary care setting and analyzed its association with patient characteristics, lifestyle habits and initiation of insulin, glucagon like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose co-transporter-2 inhibitors (SGLT-2i).MethodsData on weight, insulin, GLP-1 RA and SGLT-2i use were collected retrospectively (12 years) and prospectively (8 years) from patients included in the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1, n = 450, age 63 +/- 9 years, 58% men, diabetes duration [7-18] years). Lifestyle habits were assessed using validated questionnaires. The association of clinical parameters with body mass index (BMI) course was determined using linear mixed models. Patients who underwent bariatric surgery (n = 19) had a distinct BMI course and were excluded from the study.ResultsBaseline BMI was 31.3 (0.3) and was higher in women, patients agedConclusionsHigh BMI that real-life patients with type 2 diabetes gained earlier in life, remained stable in the following decades. Weight loss interventions should remain a priority, and GLP-1 RA might be considered to support weight loss.

AB - BackgroundAlthough weight gain increases risk of type 2 diabetes, real-life data on the weight course in patients with established type 2 diabetes are scarce. We assessed weight course in a real-life diabetes secondary care setting and analyzed its association with patient characteristics, lifestyle habits and initiation of insulin, glucagon like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose co-transporter-2 inhibitors (SGLT-2i).MethodsData on weight, insulin, GLP-1 RA and SGLT-2i use were collected retrospectively (12 years) and prospectively (8 years) from patients included in the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1, n = 450, age 63 +/- 9 years, 58% men, diabetes duration [7-18] years). Lifestyle habits were assessed using validated questionnaires. The association of clinical parameters with body mass index (BMI) course was determined using linear mixed models. Patients who underwent bariatric surgery (n = 19) had a distinct BMI course and were excluded from the study.ResultsBaseline BMI was 31.3 (0.3) and was higher in women, patients agedConclusionsHigh BMI that real-life patients with type 2 diabetes gained earlier in life, remained stable in the following decades. Weight loss interventions should remain a priority, and GLP-1 RA might be considered to support weight loss.

KW - FAT MASS

KW - TYPE-2

KW - INTERVENTIONS

KW - GAIN

KW - AGE

KW - QUESTIONNAIRE

KW - ASSOCIATIONS

KW - METAANALYSIS

KW - VALIDITY

KW - OUTCOMES

U2 - 10.1371/journal.pone.0218400

DO - 10.1371/journal.pone.0218400

M3 - Article

VL - 14

JO - PLOS-One

JF - PLOS-One

SN - 1932-6203

IS - 6

M1 - 0218400

ER -