Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice

Ming Zhou*, Eveline H. M. Bakker, Els H. Velzing, Stefan Berger, Melly Oitzl, Marian Joels, Harm J. Krugers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Scopus)

Abstract

Corticosteroid hormones are thought to promote optimal behavioral adaptation under fearful conditions primarily via glucocorticoid receptors (GRs) Here we examined - using pharmacological and genetic approaches in mice - if mineralocorticoid receptors (MRs) also play a role in fearful memory formation As expected administration of the GR-antagonist RU38486 prior to training in a fear conditioning paradigm impaired contextual memory when tested 24 (but not when tested 3) h after training Tone-cue memory was enhanced by RU38486 when tested at 4 (but not 25) h after training Interestingly pre (but not post)-training administration of MR antagonist spironolactone impaired contextual memory both at 3 and 24 h after training Similar effects were also found in forebrain-specific MR knockout mice Spironolactone also impaired tone-cue memory but only at 4 h after training These results reveal that in addition to GRs - MRs also play a critical role in establishing fear memories particularly in the early phase of memory formation (C) 2010 Elsevier Inc All rights reserved

Original languageEnglish
Pages (from-to)530-537
Number of pages8
JournalNeurobiology of Learning and Memory
Volume94
Issue number4
DOIs
Publication statusPublished - Nov-2010
Externally publishedYes

Keywords

  • Mineralocorticoid receptor
  • Glucocorticoid receptor
  • Fear conditioning
  • STRESS HORMONE CORTICOSTERONE
  • DAY-OLD CHICKS
  • SYNAPTIC POTENTIATION
  • PLASTICITY
  • BRAIN
  • CONSOLIDATION
  • HIPPOCAMPUS
  • ANTAGONISTS
  • COGNITION
  • TRANSMISSION

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