Brain Mineralocorticoid Receptors and Resilience to Stress

Sofia Kanatsou*, Marian Joels, Harm Krugers

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

    4 Citations (Scopus)

    Abstract

    Exposure to stressful experiences triggers the release of-among others-glucocorticoids from the adrenal glands. These hormones, cortisol and corticosterone in humans and rodents respectively, activate mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) that regulate neuronal activity and behavioral adaptation to stressful experiences. This review discusses molecular properties of MRs, the role of MRs in regulating neuronal function and behavior and, ultimately, evidence that enhanced MR function may confer resilience to stressful experiences.

    Original languageEnglish
    Title of host publicationALDOSTERONE
    EditorsG Litwack
    PublisherAcademic Press
    Chapter14
    Pages341-359
    Number of pages19
    Volume109
    DOIs
    Publication statusPublished - 2019

    Publication series

    NameVitamins and Hormones
    PublisherELSEVIER ACADEMIC PRESS INC
    Volume109
    ISSN (Print)0083-6729

    Keywords

    • CHRONIC PSYCHOSOCIAL STRESS
    • MESSENGER-RIBONUCLEIC-ACID
    • PITUITARY-ADRENAL AXIS
    • SPLICE VARIANTS
    • SPATIAL MEMORY
    • GLUCOCORTICOID-RECEPTORS
    • DIFFERENTIAL EXPRESSION
    • ORAL-CONTRACEPTIVES
    • CHILDHOOD TRAUMA
    • EMOTIONAL MEMORY

    Cite this