TY - JOUR
T1 - Brain organoid models for studying the function of iPSC-derived microglia in neurodegeneration and brain tumours
AU - Sabogal-Guaqueta, Angelica Maria
AU - Mitchell-Garcia, Teresa
AU - Hunneman, Jasmijn
AU - Voshart, Daniëlle
AU - Thiruvalluvan, Arun
AU - Foijer, Floris
AU - Kruyt, Frank
AU - Trombetta-Lima, Marina
AU - Eggen, Bart J.L.
AU - Boddeke, Erik
AU - Barazzuol, Lara
AU - Dolga, Amalia M.
N1 - Publisher Copyright:
© 2024
PY - 2024/12
Y1 - 2024/12
N2 - Microglia represent the main resident immune cells of the brain. The interplay between microglia and other cells in the central nervous system, such as neurons or other glial cells, influences the function and ability of microglia to respond to various stimuli. These cellular communications, when disrupted, can affect the structure and function of the brain, and the initiation and progression of neurodegenerative diseases including Alzheimer's disease and Parkinson's disease, as well as the progression of other brain diseases like glioblastoma. Due to the difficult access to patient brain tissue and the differences reported in the murine models, the available models to study the role of microglia in disease progression are limited. Pluripotent stem cell technology has facilitated the generation of highly complex models, allowing the study of control and patient-derived microglia in vitro. Moreover, the ability to generate brain organoids that can mimic the 3D tissue environment and intercellular interactions in the brain provide powerful tools to study cellular pathways under homeostatic conditions and various disease pathologies. In this review, we summarise the most recent developments in modelling degenerative diseases and glioblastoma, with a focus on brain organoids with integrated microglia. We provide an overview of the most relevant research on intercellular interactions of microglia to evaluate their potential to study brain pathologies.
AB - Microglia represent the main resident immune cells of the brain. The interplay between microglia and other cells in the central nervous system, such as neurons or other glial cells, influences the function and ability of microglia to respond to various stimuli. These cellular communications, when disrupted, can affect the structure and function of the brain, and the initiation and progression of neurodegenerative diseases including Alzheimer's disease and Parkinson's disease, as well as the progression of other brain diseases like glioblastoma. Due to the difficult access to patient brain tissue and the differences reported in the murine models, the available models to study the role of microglia in disease progression are limited. Pluripotent stem cell technology has facilitated the generation of highly complex models, allowing the study of control and patient-derived microglia in vitro. Moreover, the ability to generate brain organoids that can mimic the 3D tissue environment and intercellular interactions in the brain provide powerful tools to study cellular pathways under homeostatic conditions and various disease pathologies. In this review, we summarise the most recent developments in modelling degenerative diseases and glioblastoma, with a focus on brain organoids with integrated microglia. We provide an overview of the most relevant research on intercellular interactions of microglia to evaluate their potential to study brain pathologies.
KW - Glioblastoma
KW - iPSC
KW - Microglia
KW - Neurodegenerative diseases
KW - Organoids
UR - http://www.scopus.com/inward/record.url?scp=85210122344&partnerID=8YFLogxK
U2 - 10.1016/j.nbd.2024.106742
DO - 10.1016/j.nbd.2024.106742
M3 - Review article
AN - SCOPUS:85210122344
SN - 0969-9961
VL - 203
JO - Neurobiology of Disease
JF - Neurobiology of Disease
M1 - 106742
ER -