Brain Volumetric Correlates of Autism Spectrum Disorder Symptoms in Attention Deficit/Hyperactivity Disorder

Laurence O'Dwyer*, Colby Tanner, Eelco V. van Dongen, Corina U. Greven, Janita Braten, Marcel P. Zwiersl, Barbara Franke, Jaap Oosterlaan, Dirk Heslenfeld, Pieter Hoekstra, Catharina A. Hartman, Nanda Rommelse, Jan K. Buitelaar

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Autism spectrum disorder (ASD) symptoms frequently occur in subjects with attention deficit/hyperactivity disord (ADHD). While there is evidence that both ADHD and ASD have differential structural correlates, no study to date has nvestigated these structural correlates within a framework that robustly accounts for the phenotypic overlap between the two disorders. The presence of ASD symptoms was measured by the parent-reported Children's Social and Behavioural Questionnaire (CSBQ) in ADHD subject n = 180) their unaffected siblings (n = 118) and healthy controls (n = 146). ADHD symptoms were assessed by a structured interview K-SADS-PL) and the Conners' ADHD questionnaires. Whole brain T1 Weighted MPRAGE images were acquired and the structural MRI correlates of ASD symptom scores were analysed by modelling ASD symptom scores against white matter (WM) and grey matter (GM) volumes using mixed effects models which controlled for ADHD symptom levels. ASD symptoms were significantly elevated in ADHD subjects relative to bot h controls and unaffected siblings. ASD scores were predicted by the interaction between WM and GM volumes. Increasing ASD score was associated with greater GM volume. Equivocal results from previous structural studies in ADHD and ASD may be due to the fact that comorbidity has not been taken into account in studies to date. The current findings stress he need. to account for issues of ASD comorbidity ADHD.

Original languageEnglish
Article numbere101130
Number of pages13
JournalPLoS ONE
Volume9
Issue number6
DOIs
Publication statusPublished - 30-Jun-2014

Keywords

  • DEFICIT HYPERACTIVITY DISORDER
  • PERVASIVE DEVELOPMENTAL DISORDERS
  • BEHAVIOR QUESTIONNAIRE CSBQ
  • LARGE MULTICENTER ADHD
  • REPETITIVE BEHAVIORS
  • DIAGNOSTIC-APPROACH
  • LANGUAGE DISORDER
  • CORPUS-CALLOSUM
  • CAUDATE-NUCLEUS
  • FAMILIAL TRAIT

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