Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to ss-Nitrostyrenes Catalyzed by a Promiscuous Proline-Based Tautomerase

Ellen Zandvoort, Edzard M. Geertsema, Bert-Jan Baas, Wim J. Quax, Gerrit J. Poelarends*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

70 Citations (Scopus)
Original languageEnglish
Pages (from-to)1240-1243
Number of pages4
JournalAngewandte Chemie-International Edition
Volume51
Issue number5
DOIs
Publication statusPublished - 2012

Keywords

  • catalytic promiscuity
  • enzyme catalysis
  • Michael addition
  • organocatalysis
  • tautomerases
  • ENANTIOSELECTIVE MICHAEL ADDITION
  • CARBON BOND FORMATION
  • 4-OXALOCROTONATE TAUTOMERASE
  • MANNICH REACTION
  • ALDEHYDES
  • ALDOL
  • SUPERFAMILY
  • MALONATE
  • ENZYMES
  • KETONES

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