Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis

J. L. Mayer, L. Klumpers, S. Maslam, E. R. de Kloet, M. Joels, P. J. Lucassen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

145 Citations (Scopus)

Abstract

The glucocorticoid receptor antagonist mifepristone has been shown to rapidly and effectively ameliorate symptoms of psychotic major depression. To better understand its mechanism, we investigated mifepristone's cellular effects, and found that it rapidly reversed a chronic corticosterone-induced reduction of adult neurogenesis in rats. Unlike other antidepressants, mifepristone is particularly potent in a high corticosterone environment. These data indicate that similarly to its clinical efficacy, mifepristone's effects on adult neurogenesis are rapid and positive, and may therefore be important for its mechanism of action.

Original languageEnglish
Pages (from-to)629-631
Number of pages3
JournalJournal of Neuroendocrinology
Volume18
Issue number8
DOIs
Publication statusPublished - Aug-2006
Externally publishedYes

Keywords

  • depression
  • stress
  • neurogenesis
  • RU38486
  • doublecortin
  • RAT DENTATE GYRUS
  • MAJOR DEPRESSION
  • CHRONIC STRESS
  • BRAIN
  • EXPRESSION
  • PROLIFERATION

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