Bronchial mucus transport

Cees P. van der Schans*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

76 Citations (Scopus)

Abstract

Effective clearance of inhaled particles requires mucus production and continuous mucus transport from the lower airways to the oropharynx. Mucus production takes place mainly in the peripheral airways. Mucus transport is achieved by the action of the ciliated cells that cover the inner surface of the airways (mucociliary transport) and by expiratory airflow. The capacity for mucociliary transport is highest in the peripheral airways, whereas the capacity for airflow transport is highest in the central airways. In patients with airways disease, mucociliary transport may be impaired and airflow transport may become the most important mucus transport mechanism.

Original languageEnglish
Pages (from-to)1150-1158
Number of pages9
JournalRespiratory care
Volume52
Issue number9
Publication statusPublished - Sep-2007
Event39th Conference of the Respiratory-Care-Journal -
Duration: 1-Jan-2007 → …

Keywords

  • mucus clearance
  • cilia
  • cough
  • mucociliary transport
  • OBSTRUCTIVE LUNG-DISEASE
  • TRACHEAL MUCOUS VELOCITY
  • IMMOTILE-CILIA SYNDROME
  • GAS-LIQUID FLOW
  • MUCOCILIARY CLEARANCE
  • CYSTIC-FIBROSIS
  • TRACHEOBRONCHIAL CLEARANCE
  • BEAT FREQUENCY
  • ASTHMA
  • AIRWAYS

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