Bullous systemic lupus erythematosus

Marcel F. Jonkman, Joost M. Meijer*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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    Abstract

    Bullous systemic lupus erythematosus (BSLE) is rare heterogeneous cutaneous manifestation in patient with systemic lupus erythematosus (SLE). BSLE encompasses a subepidermal autoimmune bullous disease with type VII collagen autoantibodies, leading to epidermolysis bullosa acquisita in patients with SLE. Alternatively, an acute generalized hemorrhagic vesiculo-bullous eruption may also occur in patients with SLE caused by the extensive inflammatory reaction without the presence of type VII collagen. Vesicular eruptions can also be seen in subacute cutaneous lupus erythematosus due to severe inflammatory reaction with subepidermal clefting, which in extreme cases may resemble erythema multiforme (Rowell syndrome) or toxic epidermal necrolysis.

    Original languageEnglish
    Title of host publicationAutoimmune Bullous Diseases
    Subtitle of host publicationText and Review
    PublisherSpringer International Publishing AG
    Chapter23
    Pages137-141
    Number of pages5
    ISBN (Electronic)9783030915575
    ISBN (Print)9783030915568
    DOIs
    Publication statusPublished - 19-Jan-2022

    Keywords

    • Epidermolysis bullosa acquisita
    • Lupus erythematosus
    • Type VII collagen

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