Abstract
Background: Opioids are effective in pain-management, but long-term opioid users can develop prescription opioid use disorder (OUD). One treatment strategy in patients with OUD is rotating from a short-acting opioid to a long-acting opioid (buprenorphine/naloxone (BuNa) or methadone). Both BuNa and methadone have been shown to be effective strategies in patients with OUD reducing opioid misuse, however data on head-to-head comparison in patients with chronic non-malignant pain and prescription OUD are limited.
Methods: This two-armed open-label, randomized controlled trial aims to compare effectiveness between BuNa and methadone in patients with chronic non-malignant with prescription OUD (n=100). Participants receive inpatient rotation to either BuNa or methadone with a flexible dosing regimen.The primary outcome is opioid misuse 2 months after rotation. Secondary outcomes include treatment compliance, side effects, analgesia, opioid craving, quality of life, mood symptoms, cognitive and physical functioning over 2- and 6 months follow-up. Linear mixed model analysis will be used to evaluate change in outcome parameters over time between the treatment arms.
Discussion: This is one of the first studies comparing buprenorphine/naloxone and methadone for treating prescription OUD in a broad patient group with chronic non-malignant pain. Results may guide future treatment for patients with chronic pain and prescription OUD.
Original language | English |
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Article number | 47 |
Number of pages | 11 |
Journal | Addiction Science and Clinical Practice |
Volume | 17 |
Issue number | 1 |
DOIs | |
Publication status | Published - 4-Sep-2022 |
Keywords
- Opioid use disorder
- Methadone
- Buprenorphine/naloxone
- Chronic pain
- Current opioid misuse measure
- QUALITY-OF-LIFE
- COGNITIVE FAILURES
- NEUROPATHIC PAIN
- SUBSTANCE USE
- WHOQOL-BREF
- VALIDITY
- RELIABILITY
- MAINTENANCE
- VALIDATION
- DEPRESSION