BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

Cristina Rodriguez; Gonzalo de Gonzalo; Ana Rioz-Martinez; Daniel E. Torres Pazmino; Marco W. Fraaije; Vicente Gotor

doi:10.1039/b922693a

BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

Cristina Rodriguez, Gonzalo de Gonzalo, Ana Rioz-Martinez, Daniel E. Torres Pazmino, Marco W. Fraaije, Vicente Gotor^*

^*Corresponding author for this work

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Abstract

4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB was employed in the presence of a weak anion exchange resin to perform dynamic kinetic resolutions of racemic benzyl ketones with high conversions and good optical purities. Different parameters that affect to the efficiency of the enzymatic Baeyer-Villiger oxidation and racemisation were analyzed in order to optimize the activity and selectivity of the biocatalytic system.

Original language	English
Pages (from-to)	1121-1125
Number of pages	5
Journal	Organic & Biomolecular Chemistry
Volume	8
Issue number	5
DOIs	https://doi.org/10.1039/b922693a
Publication status	Published - 2010

Keywords

BAEYER-VILLIGER OXIDATION
PSEUDOMONAS-FLUORESCENS ACB
SECONDARY ALCOHOLS
4-HYDROXYACETOPHENONE MONOOXYGENASE
MICROBIOLOGICAL TRANSFORMATIONS
ORGANIC-SYNTHESIS
METAL
DEHYDROGENASE
REDUCTION
ENZYMES

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@article{6623a16f89cd403ea412bae97c35b228,

title = "BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins",

abstract = "4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB was employed in the presence of a weak anion exchange resin to perform dynamic kinetic resolutions of racemic benzyl ketones with high conversions and good optical purities. Different parameters that affect to the efficiency of the enzymatic Baeyer-Villiger oxidation and racemisation were analyzed in order to optimize the activity and selectivity of the biocatalytic system.",

keywords = "BAEYER-VILLIGER OXIDATION, PSEUDOMONAS-FLUORESCENS ACB, SECONDARY ALCOHOLS, 4-HYDROXYACETOPHENONE MONOOXYGENASE, MICROBIOLOGICAL TRANSFORMATIONS, ORGANIC-SYNTHESIS, METAL, DEHYDROGENASE, REDUCTION, ENZYMES",

author = "Cristina Rodriguez and {de Gonzalo}, Gonzalo and Ana Rioz-Martinez and Pazmino, {Daniel E. Torres} and Fraaije, {Marco W.} and Vicente Gotor",

year = "2010",

doi = "10.1039/b922693a",

language = "English",

volume = "8",

pages = "1121--1125",

journal = "Organic & Biomolecular Chemistry",

issn = "1477-0520",

publisher = "ROYAL SOC CHEMISTRY",

number = "5",

}

TY - JOUR

T1 - BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

AU - Rodriguez, Cristina

AU - de Gonzalo, Gonzalo

AU - Rioz-Martinez, Ana

AU - Pazmino, Daniel E. Torres

AU - Fraaije, Marco W.

AU - Gotor, Vicente

PY - 2010

Y1 - 2010

N2 - 4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB was employed in the presence of a weak anion exchange resin to perform dynamic kinetic resolutions of racemic benzyl ketones with high conversions and good optical purities. Different parameters that affect to the efficiency of the enzymatic Baeyer-Villiger oxidation and racemisation were analyzed in order to optimize the activity and selectivity of the biocatalytic system.

AB - 4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB was employed in the presence of a weak anion exchange resin to perform dynamic kinetic resolutions of racemic benzyl ketones with high conversions and good optical purities. Different parameters that affect to the efficiency of the enzymatic Baeyer-Villiger oxidation and racemisation were analyzed in order to optimize the activity and selectivity of the biocatalytic system.

KW - BAEYER-VILLIGER OXIDATION

KW - PSEUDOMONAS-FLUORESCENS ACB

KW - SECONDARY ALCOHOLS

KW - 4-HYDROXYACETOPHENONE MONOOXYGENASE

KW - MICROBIOLOGICAL TRANSFORMATIONS

KW - ORGANIC-SYNTHESIS

KW - METAL

KW - DEHYDROGENASE

KW - REDUCTION

KW - ENZYMES

U2 - 10.1039/b922693a

DO - 10.1039/b922693a

M3 - Article

SN - 1477-0520

VL - 8

SP - 1121

EP - 1125

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 5

ER -

BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

Abstract

Keywords

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