C-11 methionine PET and 18-F FDG-PET for identifying recurrent laryngeal carcinoma

    Research output: ThesisThesis fully internal (DIV)

    135 Downloads (Pure)

    Abstract

    Preservation of the larynx is an important goal in the treatment of laryngeal cancer. Laryngeal cancer is therefore usually treated with radiotherapy. The recurrence rate after therapy is on an average 30%. The differentiation between radiation reactions may be difficult. A biopsy under general anesthesia with all its negative consequences for the patient is the gold standard to confirm a recurrence. During the last decades several studies have been published which indicate that [18F]FDG-PET may detect recurrent laryngeal cancer. Our study shows that [18F] FDG -PET is an alternative for a traditional work-up, although the number false positive results remains high. We searched for alternatives to [18F] FDG. The alternative we have tested [11C] methionine reduced the number of false positive results. On the other hand the number of false negative results inclined. [11C]MET is no alternative to [18F] FDG.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • van der Laan, Bernard, Supervisor
    • Pruim, Jan, Supervisor
    • Terhaard, C.H.J., Assessment committee, External person
    • de Visscher, J. G. A. M., Assessment committee, External person
    • Slart, Riemer, Assessment committee
    Award date30-Sep-2020
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-90-830552-7-5
    DOIs
    Publication statusPublished - 2020

    Cite this